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Role of dynamic contrast-enhanced MRI in evaluating the association between contralateral parenchymal enhancement and survival outcome in ER-positive, HER2-negative, node-negative invasive breast cancer

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dc.contributor.author김민정-
dc.contributor.author김은경-
dc.contributor.author문희정-
dc.contributor.author박영진-
dc.contributor.author윤정현-
dc.date.accessioned2019-02-12T16:45:18Z-
dc.date.available2019-02-12T16:45:18Z-
dc.date.issued2018-
dc.identifier.issn1053-1807-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/167126-
dc.description.abstractBACKGROUND: Background parenchymal enhancement (BPE) on dynamic contrast-enhanced (DCE)-MRI has been associated with breast cancer risk, both based on qualitative and quantitative assessments. PURPOSE: To investigate whether BPE of the contralateral breast on preoperative DCE-MRI is associated with therapy outcome in ER-positive, HER2-negative, node-negative invasive breast cancer. STUDY TYPE: Retrospective. POPULATION: In all, 289 patients with unilateral ER-positive, HER2-negative, node-negative breast cancer larger than 5 mm. FIELD STRENGTH/SEQUENCE: 3T, T1 -weighted DCE sequence. ASSESSMENT: BPE of the contralateral breast was assessed qualitatively by two dedicated radiologists and quantitatively (using region-of-interest and automatic breast segmentation). STATISTICAL TESTS: Cox regression analysis was used to determine associations with recurrence-free survival (RFS) and distant metastasis-free survival (DFS). Interobserver variability for parenchymal enhancement was assessed using kappa statistics and intraclass correlation coefficient (ICC). RESULTS: The median follow-up time was 75.8 months. Multivariate analysis showed receipt of total mastectomy (hazard ratio [HR]: 5.497) and high Ki-67 expression level (HR: 5.956) were independent factors associated with worse RFS (P < 0.05). Only a high Ki-67 expression level was associated with worse DFS (HR: 3.571, P = 0.045). BPE assessments were not associated with outcome (RFS [qualitative BPE: P = 0.75, 0.92 for readers 1 and 2; quantitative BPE: P = 0.38-0.99], DFS, [qualitative BPE: P = 0.41, 0.16 for readers 1 and 2; quantitative BPE: P = 0.68-0.99]). For interobserver variability, there was good agreement between qualitative (κ = 0.700) and good to perfect agreement for most quantitative parameters of BPE. DATA CONCLUSION: Contralateral BPE showed no association with survival outcome in patients with ER-positive, HER2-negative, node-negative invasive breast cancer. A high Ki-67 expression level was associated with both worse recurrence-free and distant metastasis-free survival. LEVEL OF EVIDENCE: 3 Technical Efficacy: Stage 4-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-Liss-
dc.relation.isPartOfJOURNAL OF MAGNETIC RESONANCE IMAGING-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleRole of dynamic contrast-enhanced MRI in evaluating the association between contralateral parenchymal enhancement and survival outcome in ER-positive, HER2-negative, node-negative invasive breast cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학교실)-
dc.contributor.googleauthorGi Won Shin-
dc.contributor.googleauthorYang Zhang-
dc.contributor.googleauthorMin Jung Kim-
dc.contributor.googleauthorMin‐Ying Su-
dc.contributor.googleauthorEun‐Kyung Kim-
dc.contributor.googleauthorHee Jung Moon-
dc.contributor.googleauthorJung Hyun Yoon-
dc.contributor.googleauthorVivian Youngjean Park-
dc.identifier.doi10.1002/jmri.26176-
dc.contributor.localIdA00473-
dc.contributor.localIdA00801-
dc.contributor.localIdA01397-
dc.contributor.localIdA01572-
dc.contributor.localIdA02595-
dc.relation.journalcodeJ01567-
dc.identifier.eissn1522-2586-
dc.identifier.pmid29734483-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1002/jmri.26176-
dc.subject.keywordbreast cancer-
dc.subject.keywordbreast neoplasm-
dc.subject.keywordmagnetic resonance imaging-
dc.subject.keywordprognosis-
dc.subject.keywordrecurrence-
dc.contributor.alternativeNameKim, Min Jung-
dc.contributor.affiliatedAuthor김민정-
dc.contributor.affiliatedAuthor김은경-
dc.contributor.affiliatedAuthor문희정-
dc.contributor.affiliatedAuthor박영진-
dc.contributor.affiliatedAuthor윤정현-
dc.citation.volume48-
dc.citation.number6-
dc.citation.startPage1678-
dc.citation.endPage1689-
dc.identifier.bibliographicCitationJOURNAL OF MAGNETIC RESONANCE IMAGING, Vol.48(6) : 1678-1689, 2018-
dc.identifier.rimsid58106-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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