Cited 15 times in
Role of dynamic contrast-enhanced MRI in evaluating the association between contralateral parenchymal enhancement and survival outcome in ER-positive, HER2-negative, node-negative invasive breast cancer
DC Field | Value | Language |
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dc.contributor.author | 김민정 | - |
dc.contributor.author | 김은경 | - |
dc.contributor.author | 문희정 | - |
dc.contributor.author | 박영진 | - |
dc.contributor.author | 윤정현 | - |
dc.date.accessioned | 2019-02-12T16:45:18Z | - |
dc.date.available | 2019-02-12T16:45:18Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1053-1807 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/167126 | - |
dc.description.abstract | BACKGROUND: Background parenchymal enhancement (BPE) on dynamic contrast-enhanced (DCE)-MRI has been associated with breast cancer risk, both based on qualitative and quantitative assessments. PURPOSE: To investigate whether BPE of the contralateral breast on preoperative DCE-MRI is associated with therapy outcome in ER-positive, HER2-negative, node-negative invasive breast cancer. STUDY TYPE: Retrospective. POPULATION: In all, 289 patients with unilateral ER-positive, HER2-negative, node-negative breast cancer larger than 5 mm. FIELD STRENGTH/SEQUENCE: 3T, T1 -weighted DCE sequence. ASSESSMENT: BPE of the contralateral breast was assessed qualitatively by two dedicated radiologists and quantitatively (using region-of-interest and automatic breast segmentation). STATISTICAL TESTS: Cox regression analysis was used to determine associations with recurrence-free survival (RFS) and distant metastasis-free survival (DFS). Interobserver variability for parenchymal enhancement was assessed using kappa statistics and intraclass correlation coefficient (ICC). RESULTS: The median follow-up time was 75.8 months. Multivariate analysis showed receipt of total mastectomy (hazard ratio [HR]: 5.497) and high Ki-67 expression level (HR: 5.956) were independent factors associated with worse RFS (P < 0.05). Only a high Ki-67 expression level was associated with worse DFS (HR: 3.571, P = 0.045). BPE assessments were not associated with outcome (RFS [qualitative BPE: P = 0.75, 0.92 for readers 1 and 2; quantitative BPE: P = 0.38-0.99], DFS, [qualitative BPE: P = 0.41, 0.16 for readers 1 and 2; quantitative BPE: P = 0.68-0.99]). For interobserver variability, there was good agreement between qualitative (κ = 0.700) and good to perfect agreement for most quantitative parameters of BPE. DATA CONCLUSION: Contralateral BPE showed no association with survival outcome in patients with ER-positive, HER2-negative, node-negative invasive breast cancer. A high Ki-67 expression level was associated with both worse recurrence-free and distant metastasis-free survival. LEVEL OF EVIDENCE: 3 Technical Efficacy: Stage 4 | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley-Liss | - |
dc.relation.isPartOf | JOURNAL OF MAGNETIC RESONANCE IMAGING | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Role of dynamic contrast-enhanced MRI in evaluating the association between contralateral parenchymal enhancement and survival outcome in ER-positive, HER2-negative, node-negative invasive breast cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학교실) | - |
dc.contributor.googleauthor | Gi Won Shin | - |
dc.contributor.googleauthor | Yang Zhang | - |
dc.contributor.googleauthor | Min Jung Kim | - |
dc.contributor.googleauthor | Min‐Ying Su | - |
dc.contributor.googleauthor | Eun‐Kyung Kim | - |
dc.contributor.googleauthor | Hee Jung Moon | - |
dc.contributor.googleauthor | Jung Hyun Yoon | - |
dc.contributor.googleauthor | Vivian Youngjean Park | - |
dc.identifier.doi | 10.1002/jmri.26176 | - |
dc.contributor.localId | A00473 | - |
dc.contributor.localId | A00801 | - |
dc.contributor.localId | A01397 | - |
dc.contributor.localId | A01572 | - |
dc.contributor.localId | A02595 | - |
dc.relation.journalcode | J01567 | - |
dc.identifier.eissn | 1522-2586 | - |
dc.identifier.pmid | 29734483 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/full/10.1002/jmri.26176 | - |
dc.subject.keyword | breast cancer | - |
dc.subject.keyword | breast neoplasm | - |
dc.subject.keyword | magnetic resonance imaging | - |
dc.subject.keyword | prognosis | - |
dc.subject.keyword | recurrence | - |
dc.contributor.alternativeName | Kim, Min Jung | - |
dc.contributor.affiliatedAuthor | 김민정 | - |
dc.contributor.affiliatedAuthor | 김은경 | - |
dc.contributor.affiliatedAuthor | 문희정 | - |
dc.contributor.affiliatedAuthor | 박영진 | - |
dc.contributor.affiliatedAuthor | 윤정현 | - |
dc.citation.volume | 48 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1678 | - |
dc.citation.endPage | 1689 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MAGNETIC RESONANCE IMAGING, Vol.48(6) : 1678-1689, 2018 | - |
dc.identifier.rimsid | 58106 | - |
dc.type.rims | ART | - |
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