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Expression of EpCAM in adenoid cystic carcinoma

 Seok Joo Lee  ;  Kee Yang Chung  ;  Ji Eun Kwon  ;  Sun Och Yoon  ;  Sang Kyum Kim 
 PATHOLOGY, Vol.50(7) : 737-741, 2018 
Journal Title
Issue Date
Adult ; Aged ; Aged, 80 and over ; Biomarkers/metabolism ; Carcinoma, Adenoid Cystic/diagnosis ; Carcinoma, Adenoid Cystic/metabolism ; Carcinoma, Adenoid Cystic/pathology* ; Epithelial Cell Adhesion Molecule/genetics ; Epithelial Cell Adhesion Molecule/metabolism* ; Female ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Neoplasm Metastasis ; Prognosis ; Progression-Free Survival ; Retrospective Studies ; Salivary Gland Neoplasms/diagnosis ; Salivary Gland Neoplasms/metabolism ; Salivary Gland Neoplasms/pathology* ; Salivary Glands/metabolism ; Salivary Glands/pathology ; Tissue Array Analysis ; Young Adult
Adenoid cystic carcinoma ; Ber-EP4 ; EpCAM ; biomarker ; non-salivary gland
The mutational landscape of adenoid cystic carcinoma (ACC) is currently being revealed, but further studies are needed to identify biomarkers as therapeutic targets or prognostic factors of ACC. In this study, we investigated the expression of epithelial cell adhesion molecule (EpCAM) in ACCs. We retrospectively collected 83 cases of surgically resected ACCs. Using tissue microarray, we conducted immunohistochemical staining using the anti-EpCAM antibody. EpCAM expression was analysed by intensity score and the total immunostaining score. The positivity was 97.6% (81/83 cases), regardless of the intensity score. A higher histological grade (p = 0.006) and specific tumour location (non-salivary gland origin, p = 0.02) showed a correlation with higher EpCAM intensity. Higher EpCAM expression by total immunostaining score was associated with histological grade (p = 0.004), distant metastasis (p = 0.004) and poorer prognosis (overall survival p = 0.015 and progression-free survival p = 0.033). We suggest EpCAM as a candidate prognostic marker and a putative therapeutic target in ACC. Also, ACCs arising from salivary gland and non-salivary gland sites, respectively, might display different pathophysiologies in which EpCAM could play a role.
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1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sang Kyum(김상겸) ORCID logo https://orcid.org/0000-0003-0768-9923
Yoon, Sun Och(윤선옥) ORCID logo https://orcid.org/0000-0002-5115-1402
Chung, Kee Yang(정기양) ORCID logo https://orcid.org/0000-0003-3257-0297
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