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Environmental disinfection with photocatalyst as an adjunctive measure to control transmission of methicillin-resistant Staphylococcus aureus: a prospective cohort study in a high-incidence setting

Authors
 Min Hyung Kim  ;  Seong Gyu Lee  ;  Ki Sook Kim  ;  Yoon Ji Heo  ;  Ji Eun Oh  ;  Su Jin Jeong 
Citation
 BMC Infectious Diseases, Vol.18(1) : 610, 2018 
Journal Title
 BMC Infectious Diseases 
Issue Date
2018
Keywords
Environmental disinfection ; Hospital-acquired infection ; MRSA ; Photocatalyst
Abstract
BACKGROUND: Environmental disinfection with continuously antimicrobial surfaces could offer superior control of surface bioburden. We sought to decide the efficacy of photocatalyst antimicrobial coating in reducing methicillin-resistant Staphylococcus aureus (MRSA) acquisition in high incidence setting. METHODS: We performed prospective cohort study involving patients hospitalized in medical intensive care unit. A titanium dioxide-based photocatalyst was coated on high touch surfaces and walls. Five months of pre-intervention data were compared with five months of post-intervention data. The incidence rates of multidrug-resistant organism acquisition and the rates of hospital-acquired blood stream infection, pneumonia, urinary tract infection, and Clostridium difficile-associated diseases were compared using Cox proportional hazards regression analysis. RESULTS: In total, 621 patients were included. There was significant decrease in MRSA acquisition rate after photocatalyst coating (hazard ratio, 0.37; 95% confidence interval, 0.14-0.99; p = 0.04). However, clinical identification of vancomycin-resistant Enterococcus spp. and multidrug-resistant Acinetobacter baumannii did not decrease significantly. The hazard of contracting hospital-acquired pneumonia during the intervention period compared to baseline period was 0.46 (95% confidence interval, 0.23-0.94; p = 0.03). CONCLUSIONS: In conclusion, MRSA rate was significantly reduced after photocatalyst coating. We provide evidence that photocatalyst disinfection can be an adjunctive measure to control MRSA acquisition in high-incidence settings. TRIAL REGISTRATION: ISRCTN Registry ( ISRCTN31972004 ). Registered retrospectively on November 19, 2018.
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T201804883.pdf.pdf Download
DOI
10.1186/s12879-018-3555-1
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
정수진(Jeong, Su Jin) ORCID logo https://orcid.org/0000-0003-4025-4542
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/166841
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