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Multidisciplinary treatment for patients with stage IV gastric cancer: the role of conversion surgery following chemotherapy

DC FieldValueLanguage
dc.contributor.author김형일-
dc.contributor.author김효송-
dc.contributor.author노성훈-
dc.contributor.author라선영-
dc.contributor.author백송이-
dc.contributor.author범승훈-
dc.contributor.author손태일-
dc.contributor.author임준석-
dc.contributor.author정민규-
dc.contributor.author정재호-
dc.contributor.author정희철-
dc.contributor.author최승호-
dc.contributor.author최윤영-
dc.contributor.author형우진-
dc.date.accessioned2019-01-15T16:53:30Z-
dc.date.available2019-01-15T16:53:30Z-
dc.date.issued2018-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/166705-
dc.description.abstractBACKGROUND: With advances in gastric cancer chemotherapy, conversion surgery has drawn attention as a new strategy to improve the outcome of stage IV disease. We investigated the efficacy of conversion surgery following chemotherapy for patients with stage IV gastric cancer. METHODS: We retrospectively reviewed clinico-pathologic variables and oncologic outcomes for 101 patients with stage IV gastric cancer who were treated with systemic chemotherapy followed by gastrectomy with intension of curative resection from January 2005 to December 2012. RESULTS: In terms of the best response from palliative chemotherapy, complete or partial response were observed in 65 patients (64.4%) in overall. Complete response of metastatic site were observed in 72 (71.3%) and 66 (65.3%) patients as best and pre-operative response, respectively. The overall complete macroscopic resection, rate was 56.4%. Eleven patients (10.9%) received combined metastasectomy. There was no postoperative surgery-related mortality for 1 month. The median overall survival time was 26.0 months. Multivariable analysis identified complete macroscopic resection, chemotherapy response (complete response/partial response) of metastatic sites, and change in CEA level as independent prognostic factors contributing to overall survival. CONCLUSIONS: Patients with stage IV gastric cancer who exhibit a good clinical response to chemotherapy might obtain greater survival benefit from gastrectomy following chemotherapy compared with patients who exhibit a poor response to chemotherapy. Prospective, randomized trials are required to determine the best strategy for combining initial chemotherapy with subsequent gastrectomy.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherBioMed Central-
dc.relation.isPartOfBMC Cancer-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleMultidisciplinary treatment for patients with stage IV gastric cancer: the role of conversion surgery following chemotherapy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorSeung-Hoon Beom-
dc.contributor.googleauthorYoon Young Choi-
dc.contributor.googleauthorSong-Ee Baek-
dc.contributor.googleauthorShuang-Xi Li-
dc.contributor.googleauthorJoon Seok Lim-
dc.contributor.googleauthorTaeil Son-
dc.contributor.googleauthorHyoung-Il Kim-
dc.contributor.googleauthorJae-Ho Cheong-
dc.contributor.googleauthorWoo Jin Hyung-
dc.contributor.googleauthorSeung Ho Choi-
dc.contributor.googleauthorMinkyu Jung-
dc.contributor.googleauthorHyo Song Kim-
dc.contributor.googleauthorHei-Cheul Jeung-
dc.contributor.googleauthorHyun Cheol Chung-
dc.contributor.googleauthorSun Young Rha-
dc.contributor.googleauthorSung Hoon Noh-
dc.identifier.doi10.1186/s12885-018-4998-x-
dc.contributor.localIdA01154-
dc.contributor.localIdA01202-
dc.contributor.localIdA01202-
dc.contributor.localIdA01281-
dc.contributor.localIdA01281-
dc.contributor.localIdA01316-
dc.contributor.localIdA01316-
dc.contributor.localIdA01822-
dc.contributor.localIdA01822-
dc.contributor.localIdA04581-
dc.contributor.localIdA04581-
dc.contributor.localIdA01998-
dc.contributor.localIdA01998-
dc.contributor.localIdA03408-
dc.contributor.localIdA03408-
dc.contributor.localIdA03606-
dc.contributor.localIdA03606-
dc.contributor.localIdA03717-
dc.contributor.localIdA03717-
dc.contributor.localIdA03794-
dc.contributor.localIdA03794-
dc.contributor.localIdA04102-
dc.contributor.localIdA04102-
dc.contributor.localIdA04138-
dc.contributor.localIdA04138-
dc.contributor.localIdA04382-
dc.contributor.localIdA04382-
dc.relation.journalcodeJ00351-
dc.identifier.eissn1471-2407-
dc.identifier.pmid30442107-
dc.subject.keywordChemotherapy-
dc.subject.keywordConversion surgery-
dc.subject.keywordGastrectomy-
dc.subject.keywordGastric cancer-
dc.subject.keywordMetastasis-
dc.contributor.alternativeNameKim, Hyoung Il-
dc.contributor.affiliatedAuthor김형일-
dc.contributor.affiliatedAuthor김효송-
dc.contributor.affiliatedAuthor김효송-
dc.contributor.affiliatedAuthor노성훈-
dc.contributor.affiliatedAuthor노성훈-
dc.contributor.affiliatedAuthor라선영-
dc.contributor.affiliatedAuthor라선영-
dc.contributor.affiliatedAuthor백송이-
dc.contributor.affiliatedAuthor백송이-
dc.contributor.affiliatedAuthor범승훈-
dc.contributor.affiliatedAuthor범승훈-
dc.contributor.affiliatedAuthor손태일-
dc.contributor.affiliatedAuthor손태일-
dc.contributor.affiliatedAuthor임준석-
dc.contributor.affiliatedAuthor임준석-
dc.contributor.affiliatedAuthor정민규-
dc.contributor.affiliatedAuthor정민규-
dc.contributor.affiliatedAuthor정재호-
dc.contributor.affiliatedAuthor정재호-
dc.contributor.affiliatedAuthor정희철-
dc.contributor.affiliatedAuthor정희철-
dc.contributor.affiliatedAuthor최승호-
dc.contributor.affiliatedAuthor최승호-
dc.contributor.affiliatedAuthor최윤영-
dc.contributor.affiliatedAuthor최윤영-
dc.contributor.affiliatedAuthor형우진-
dc.contributor.affiliatedAuthor형우진-
dc.citation.volume18-
dc.citation.number1-
dc.citation.startPage1116-
dc.identifier.bibliographicCitationBMC Cancer, Vol.18(1) : 1116, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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