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iNKT Cells Suppress Pathogenic NK1.1+CD8+ T Cells in DSS-Induced Colitis

Authors
 Sung Won Lee  ;  Hyun Jung Park  ;  Jae Hee Cheon  ;  Lan Wu  ;  Luc Van Kaer  ;  Seokmann Hong 
Citation
 FRONTIERS IN IMMUNOLOGY, Vol.9 : 2168, 2018 
Journal Title
 FRONTIERS IN IMMUNOLOGY 
Issue Date
2018
Keywords
CD1d-dependent NKT cells ; DSS-induced colitis ; IFNγ ; NK1.1+CD8+ T cells ; Treg cells
Abstract
T cells producing IFNγ play a pathogenic role in the development of inflammatory bowel disease (IBD). To investigate the functions of CD1d-dependent invariant natural killer T (iNKT) cells in experimental colitis induced in Yeti mice with dysregulated expression of IFNγ, we generated iNKT cell-deficient Yeti/CD1d KO mice and compared colitis among WT, CD1d KO, Yeti, and Yeti/CD1d KO mice following DSS treatment. We found that deficiency of iNKT cells exacerbated colitis and disease pathogenesis was mainly mediated by NK1.1+CD8+ T cells. Furthermore, the protective effects of iNKT cells correlated with up-regulation of regulatory T cells. Taken together, our results have demonstrated that CD1d-dependent iNKT cells and CD1d-independent NK1.1+CD8+ T cells reciprocally regulate the development of intestinal inflammatory responses mediated by IFNγ-dysregulation. These findings also identify NK1.1+CD8+ T cells as novel target cells for the development of therapeutics for human IBD.
Files in This Item:
T201804323.pdf.pdf Download
DOI
10.3389/fimmu.2018.02168
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Cheon, Jae Hee(천재희) ORCID logo https://orcid.org/0000-0002-2282-8904
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/166649
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