Cited 17 times in
iNKT Cells Suppress Pathogenic NK1.1+CD8+ T Cells in DSS-Induced Colitis
DC Field | Value | Language |
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dc.contributor.author | 천재희 | - |
dc.date.accessioned | 2019-01-15T16:48:06Z | - |
dc.date.available | 2019-01-15T16:48:06Z | - |
dc.date.issued | 2018 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/166649 | - |
dc.description.abstract | T cells producing IFNγ play a pathogenic role in the development of inflammatory bowel disease (IBD). To investigate the functions of CD1d-dependent invariant natural killer T (iNKT) cells in experimental colitis induced in Yeti mice with dysregulated expression of IFNγ, we generated iNKT cell-deficient Yeti/CD1d KO mice and compared colitis among WT, CD1d KO, Yeti, and Yeti/CD1d KO mice following DSS treatment. We found that deficiency of iNKT cells exacerbated colitis and disease pathogenesis was mainly mediated by NK1.1+CD8+ T cells. Furthermore, the protective effects of iNKT cells correlated with up-regulation of regulatory T cells. Taken together, our results have demonstrated that CD1d-dependent iNKT cells and CD1d-independent NK1.1+CD8+ T cells reciprocally regulate the development of intestinal inflammatory responses mediated by IFNγ-dysregulation. These findings also identify NK1.1+CD8+ T cells as novel target cells for the development of therapeutics for human IBD. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Frontiers Research Foundation | - |
dc.relation.isPartOf | FRONTIERS IN IMMUNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | iNKT Cells Suppress Pathogenic NK1.1+CD8+ T Cells in DSS-Induced Colitis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Sung Won Lee | - |
dc.contributor.googleauthor | Hyun Jung Park | - |
dc.contributor.googleauthor | Jae Hee Cheon | - |
dc.contributor.googleauthor | Lan Wu | - |
dc.contributor.googleauthor | Luc Van Kaer | - |
dc.contributor.googleauthor | Seokmann Hong | - |
dc.identifier.doi | 10.3389/fimmu.2018.02168 | - |
dc.contributor.localId | A04030 | - |
dc.relation.journalcode | J03075 | - |
dc.identifier.eissn | 1664-3224 | - |
dc.identifier.pmid | 30333822 | - |
dc.subject.keyword | CD1d-dependent NKT cells | - |
dc.subject.keyword | DSS-induced colitis | - |
dc.subject.keyword | IFNγ | - |
dc.subject.keyword | NK1.1+CD8+ T cells | - |
dc.subject.keyword | Treg cells | - |
dc.contributor.alternativeName | Cheon, Jae Hee | - |
dc.contributor.affiliatedAuthor | 천재희 | - |
dc.citation.volume | 9 | - |
dc.citation.startPage | 2168 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN IMMUNOLOGY, Vol.9 : 2168, 2018 | - |
dc.identifier.rimsid | 57921 | - |
dc.type.rims | ART | - |
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