Cited 19 times in
Computed tomography characteristics of lung adenocarcinomas with epidermal growth factor receptor mutation: A propensity score matching study
DC Field | Value | Language |
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dc.contributor.author | 서영주 | - |
dc.date.accessioned | 2019-01-15T16:47:43Z | - |
dc.date.available | 2019-01-15T16:47:43Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0169-5002 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/166643 | - |
dc.description.abstract | OBJECTIVES: We investigated the relationship between computed tomography (CT) characteristics and epidermal growth factor receptor (EGFR) mutations in a large Asian cohort who received surgical resection of invasive lung adenocarcinoma. MATERIALS AND METHODS: We retrospectively included 864 patients (524 with EGFR mutation and 340 with EGFR wild-type) who received surgical resections for invasive lung adenocarcinomas. After applying propensity score matching, 312 patients with mutated EGFR were matched with 312 patients with wild-type EGFR. CT characteristics, predominant histologic subtype, and CT measurement parameters (volume and estimated diameter of the total tumor and inner solid portion and ground-glass opacity [GGO] proportion) were compared within matched pairs. RESULTS: Tumors in the EGFR mutation group showed higher proportions of pure ground-glass nodules (4.1% vs 1.3%), GGO-predominant (23.7% vs 14.7%), and solid-predominant part-solid nodules (37.2% vs 31.7%) CT characteristics, whereas EGFR wild-type tumors predominantly presented as pure solid nodules (34.6% vs 52.2%, P < 0.0001). EGFR mutation tumors more frequently had a lepidic-predominant subtype than did EGFR wild-type tumors (20.2% and 11.9%; P < 0.0001), and showed a smaller whole tumor size and solid portion (P < 0.0001) with a higher GGO proportion (P < 0.0001). Tumors with exon 21 missense mutations showed the highest GGO proportion and the smallest inner solid portion size, followed by tumors harboring an exon 19 deletion, compared with EGFR wild-type tumors (posthoc P < 0.01). CONCLUSION: Adenocarcinomas with EGFR mutations had a higher GGO proportion than those with wild-type EGFR after matching of clinical variables. Lesions with an exon 21 mutation had a higher GGO proportion than lesions with other mutations. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Scientific Publishers | - |
dc.relation.isPartOf | LUNG CANCER | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Computed tomography characteristics of lung adenocarcinomas with epidermal growth factor receptor mutation: A propensity score matching study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학교실) | - |
dc.contributor.googleauthor | Young Joo Suh | - |
dc.contributor.googleauthor | Hyun-Ju Lee | - |
dc.contributor.googleauthor | Young Jae Kim | - |
dc.contributor.googleauthor | Kwang Gi Kim | - |
dc.contributor.googleauthor | Heekyung Kim | - |
dc.contributor.googleauthor | Yoon Kyung Jeon | - |
dc.contributor.googleauthor | Young Tae Kim | - |
dc.identifier.doi | 10.1016/j.lungcan.2018.06.030 | - |
dc.contributor.localId | A01892 | - |
dc.relation.journalcode | J02174 | - |
dc.identifier.eissn | 1872-8332 | - |
dc.identifier.pmid | 30089595 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0169500218304392 | - |
dc.subject.keyword | Computed tomography | - |
dc.subject.keyword | EGFR mutation | - |
dc.subject.keyword | Lung adenocarcinoma | - |
dc.contributor.alternativeName | Suh, Young Joo | - |
dc.contributor.affiliatedAuthor | 서영주 | - |
dc.citation.volume | 123 | - |
dc.citation.startPage | 52 | - |
dc.citation.endPage | 59 | - |
dc.identifier.bibliographicCitation | LUNG CANCER, Vol.123 : 52-59, 2018 | - |
dc.identifier.rimsid | 57915 | - |
dc.type.rims | ART | - |
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