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Varicella zoster virus-associated Chorioretinitis: a case report

 Joo Yeon Kim  ;  Ji Hwan Lee  ;  Christopher Seungkyu Lee  ;  Sung Chul Lee 
 BMC OPHTHALMOLOGY, Vol.18(1) : 28, 2018 
Journal Title
Issue Date
Acyclovir/therapeutic use ; Administration, Oral ; Antiviral Agents/therapeutic use ; Chorioretinitis/diagnosis ; Chorioretinitis/drug therapy ; Chorioretinitis/virology* ; Combined Modality Therapy ; Eye Infections, Viral/diagnosis ; Eye Infections, Viral/drug therapy ; Eye Infections, Viral/virology* ; Female ; Fluorescein Angiography ; Glucocorticoids/therapeutic use ; Herpesvirus 3, Human/isolation & purification* ; Humans ; Middle Aged ; Prednisolone/therapeutic use ; Tomography, Optical Coherence ; Uveitis, Posterior/diagnosis ; Uveitis, Posterior/drug therapy ; Uveitis, Posterior/virology* ; Varicella Zoster Virus Infection/diagnosis ; Varicella Zoster Virus Infection/drug therapy ; Varicella Zoster Virus Infection/virology*
Chorioretinitis ; Herpesvirus 3 ; Human ; Uveitis
BACKGROUND: Chorioretinitis is an unusual form of varicella zoster virus (VZV)-associated uveitis, and no report has described VZV-associated chorioretinitis using serial optical coherence tomography (OCT) images obtained during the course of resolution.

CASE PRESENTATION: A 61-year-old woman presented with acute, unilateral vision loss in her right eye. Her visual acuity was count fingers in the right eye and 16/20 in the left eye, and she exhibited skin vesicles on her right forehead. Slit lamp biomicroscopy, funduscopy, OCT, and intraocular fluid analysis were performed. The right eye exhibited multiple inflammatory lesions at the posterior pole, macular edema, and disc swelling on the fundus examination. OCT revealed predominant involvement of the choroid and the retinal pigment epithelium (RPE). Intraocular fluid analysis showed positivity for VZV. The patient was admitted and treated with intravenous acyclovir. Additional oral prednisolone was used to reduce the inflammatory reaction. After 2 weeks of treatment with acyclovir, the lesion resolved, with undulation of the RPE. Her final visual acuity was 20/20.

CONCLUSIONS: VZV-associated posterior uveitis may present as multifocal chorioretinitis. Intraocular fluid analysis is important to detect an infectious origin.
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1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Sung Chul(이성철) ORCID logo https://orcid.org/0000-0001-9438-2385
Lee, Christopher Seungkyu(이승규) ORCID logo https://orcid.org/0000-0001-5054-9470
Lee, Ji Hwan(이지환) ORCID logo https://orcid.org/0000-0003-1759-8195
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