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Low dose versus conventional dose of intravitreal bevacizumab injection for retinopathy of prematurity: a case series with paired-eye comparison

Authors
 Jinu Han  ;  Seong Eun Kim  ;  Sung Chul Lee  ;  Christopher Seungkyu Lee 
Citation
 ACTA OPHTHALMOLOGICA, Vol.96(4) : e475-e478, 2018 
Journal Title
 ACTA OPHTHALMOLOGICA 
ISSN
 1755-375X 
Issue Date
2018
MeSH
Angiogenesis Inhibitors/administration & dosage ; Bevacizumab/administration & dosage* ; Dose-Response Relationship, Drug ; Female ; Follow-Up Studies ; Gestational Age ; Humans ; Infant, Newborn ; Infant, Premature* ; Intravitreal Injections ; Laser Coagulation ; Male ; Receptors, Vascular Endothelial Growth Factor/antagonists & inhibitors ; Retinopathy of Prematurity/drug therapy* ; Retinopathy of Prematurity/surgery
Keywords
anti-VEGF therapy ; intravitreal bevacizumab ; retinopathy of prematurity ; vascular endothelial growth factor
Abstract
PURPOSE: To compare the clinical outcomes of intravitreal bevacizumab (IVB) injection, with different dosing (0.25 mg/0.01 ml versus 0.625 mg/0.025 ml) in each eye of the same patient with retinopathy of prematurity (ROP). METHODS: Intravitreal bevacizumab (IVB) was injected into eight patients with stage 3+ in zone I or posterior zone II ROP (16 eyes). Bevacizumab, with different dosing (0.25 mg/0.01 ml and 0.625 mg/0.025 ml), was injected into the vitreous cavity of each eye. RESULTS: Among the 16 eyes treated with IVB, six eyes had zone I ROP and 10 eyes had zone II ROP. The mean birthweight was 800 ± 139 g (range, 533-955 g), and the mean gestational age was 25.9 ± 1.2 gestational weeks (range, 24.4-28.7 weeks). The postmenstrual age at initial treatment was 37.2 gestational weeks (range, 33.7-41 weeks). The mean follow-up was 312 ± 50 days (median, 305 days; range, 238-376 days). All eyes showed regression of plus sign after IVB injection within 1 week and revascularization to the ora serrata at the time of final visit. There was no difference in the time of anatomical achievement between the eyes with different doses. None of the patients received any additional IVB injection or laser photocoagulation. After the regression of ROP, tractional retinal detachment and macular ectopia were not observed in any patients during follow-up. CONCLUSIONS: There was no difference in the short-term clinical outcomes of stage 3+ ROP in zone I or II between the eyes with low dose and conventional dose of IVB.
Full Text
https://onlinelibrary.wiley.com/doi/full/10.1111/aos.13004
DOI
10.1111/aos.13004
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seong Eun(김성은) ORCID logo https://orcid.org/0000-0002-8537-9798
Lee, Sung Chul(이성철) ORCID logo https://orcid.org/0000-0001-9438-2385
Lee, Christopher Seungkyu(이승규) ORCID logo https://orcid.org/0000-0001-5054-9470
Han, Jinu(한진우) ORCID logo https://orcid.org/0000-0002-8607-6625
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/166608
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