Cited 18 times in

Association among T2 signal intensity, necrosis, ADC and Ki-67 in estrogen receptor-positive and HER2-negative invasive ductal carcinoma

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dc.contributor.author구자승-
dc.contributor.author김민정-
dc.contributor.author김은경-
dc.contributor.author문희정-
dc.contributor.author윤정현-
dc.date.accessioned2019-01-15T16:43:54Z-
dc.date.available2019-01-15T16:43:54Z-
dc.date.issued2018-
dc.identifier.issn0730-725X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/166606-
dc.description.abstractPURPOSE: To determine whether T2 signal intensity, necrosis, and ADC values are associated with Ki-67 in patients with Estrogen Receptor (ER)-positive and Human epidermal growth factor receptor type 2 (HER2)-negative invasive ductal carcinoma (IDC). MATERIALS AND METHODS: Between March 2012 and February 2013, one hundred eighty seven women with ER-positive and HER2-negative IDC who underwent breast MRI and subsequent surgery were included. Intratumoral signal intensity was evaluated based on a combination of T2-weighted (low or equal, high, or very high) and contrast-enhanced MR images (enhancement or not). Necrosis was defined as very high T2 and no enhancement. Using the analysis of variance and pairwise t-test, a model based on intratumoral signal intensity was developed to assess Ki-67 of the surgical specimen. Inter-observer agreement for the developed model was analyzed. Conventional mean and minimum apparent diffusion coefficient (ADC) measurements were performed and correlated with Ki-67. RESULTS: As the grade of the developed model increased (Grade I: low or equal T2, Grade II: high T2, or necrosis < 50%, Grade III: necrosis ≥ 50%), mean Ki-67 significantly increased (Grade I to III: 12.5%, 17.6%, 45.0%, respectively; P < 0.001). Good inter-observer agreement was found for the model (κ = 0.846, P < 0.001). ADC did not show significant correlations with Ki-67 (Pearson's correlation coefficient, 0.140 [P = 0.057] for mean ADC; -0.079 [P = 0.284] for minimum ADC). CONCLUSION: Intratumoral signal intensity but not ADC was associated with Ki-67 in patients with ER-positive and HER2-negative IDC.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfMAGNETIC RESONANCE IMAGING-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleAssociation among T2 signal intensity, necrosis, ADC and Ki-67 in estrogen receptor-positive and HER2-negative invasive ductal carcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학교실)-
dc.contributor.googleauthorSoo-Yeon Kim-
dc.contributor.googleauthorEun-Kyung Kim-
dc.contributor.googleauthorHee Jung Moon-
dc.contributor.googleauthorJung Hyun Yoon-
dc.contributor.googleauthorJa Seung Koo-
dc.contributor.googleauthorSungheon Gene Kim-
dc.contributor.googleauthorMin Jung Kim-
dc.identifier.doi10.1016/j.mri.2018.08.017-
dc.contributor.localIdA00198-
dc.contributor.localIdA00473-
dc.contributor.localIdA00801-
dc.contributor.localIdA01397-
dc.contributor.localIdA02595-
dc.relation.journalcodeJ02178-
dc.identifier.eissn1873-5894-
dc.identifier.pmid30172938-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0730725X18301784-
dc.subject.keywordApparent diffusion coefficient-
dc.subject.keywordKi-67-
dc.subject.keywordMagnetic resonance imaging-
dc.subject.keywordNecrosis-
dc.subject.keywordT2 signal intensity-
dc.contributor.alternativeNameKoo, Ja Seung-
dc.contributor.affiliatedAuthor구자승-
dc.contributor.affiliatedAuthor김민정-
dc.contributor.affiliatedAuthor김은경-
dc.contributor.affiliatedAuthor문희정-
dc.contributor.affiliatedAuthor윤정현-
dc.citation.volume54-
dc.citation.startPage176-
dc.citation.endPage182-
dc.identifier.bibliographicCitationMAGNETIC RESONANCE IMAGING, Vol.54 : 176-182, 2018-
dc.identifier.rimsid57882-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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