Cited 18 times in
Association among T2 signal intensity, necrosis, ADC and Ki-67 in estrogen receptor-positive and HER2-negative invasive ductal carcinoma
DC Field | Value | Language |
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dc.contributor.author | 구자승 | - |
dc.contributor.author | 김민정 | - |
dc.contributor.author | 김은경 | - |
dc.contributor.author | 문희정 | - |
dc.contributor.author | 윤정현 | - |
dc.date.accessioned | 2019-01-15T16:43:54Z | - |
dc.date.available | 2019-01-15T16:43:54Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0730-725X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/166606 | - |
dc.description.abstract | PURPOSE: To determine whether T2 signal intensity, necrosis, and ADC values are associated with Ki-67 in patients with Estrogen Receptor (ER)-positive and Human epidermal growth factor receptor type 2 (HER2)-negative invasive ductal carcinoma (IDC). MATERIALS AND METHODS: Between March 2012 and February 2013, one hundred eighty seven women with ER-positive and HER2-negative IDC who underwent breast MRI and subsequent surgery were included. Intratumoral signal intensity was evaluated based on a combination of T2-weighted (low or equal, high, or very high) and contrast-enhanced MR images (enhancement or not). Necrosis was defined as very high T2 and no enhancement. Using the analysis of variance and pairwise t-test, a model based on intratumoral signal intensity was developed to assess Ki-67 of the surgical specimen. Inter-observer agreement for the developed model was analyzed. Conventional mean and minimum apparent diffusion coefficient (ADC) measurements were performed and correlated with Ki-67. RESULTS: As the grade of the developed model increased (Grade I: low or equal T2, Grade II: high T2, or necrosis < 50%, Grade III: necrosis ≥ 50%), mean Ki-67 significantly increased (Grade I to III: 12.5%, 17.6%, 45.0%, respectively; P < 0.001). Good inter-observer agreement was found for the model (κ = 0.846, P < 0.001). ADC did not show significant correlations with Ki-67 (Pearson's correlation coefficient, 0.140 [P = 0.057] for mean ADC; -0.079 [P = 0.284] for minimum ADC). CONCLUSION: Intratumoral signal intensity but not ADC was associated with Ki-67 in patients with ER-positive and HER2-negative IDC. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | MAGNETIC RESONANCE IMAGING | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Association among T2 signal intensity, necrosis, ADC and Ki-67 in estrogen receptor-positive and HER2-negative invasive ductal carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Soo-Yeon Kim | - |
dc.contributor.googleauthor | Eun-Kyung Kim | - |
dc.contributor.googleauthor | Hee Jung Moon | - |
dc.contributor.googleauthor | Jung Hyun Yoon | - |
dc.contributor.googleauthor | Ja Seung Koo | - |
dc.contributor.googleauthor | Sungheon Gene Kim | - |
dc.contributor.googleauthor | Min Jung Kim | - |
dc.identifier.doi | 10.1016/j.mri.2018.08.017 | - |
dc.contributor.localId | A00198 | - |
dc.contributor.localId | A00473 | - |
dc.contributor.localId | A00801 | - |
dc.contributor.localId | A01397 | - |
dc.contributor.localId | A02595 | - |
dc.relation.journalcode | J02178 | - |
dc.identifier.eissn | 1873-5894 | - |
dc.identifier.pmid | 30172938 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0730725X18301784 | - |
dc.subject.keyword | Apparent diffusion coefficient | - |
dc.subject.keyword | Ki-67 | - |
dc.subject.keyword | Magnetic resonance imaging | - |
dc.subject.keyword | Necrosis | - |
dc.subject.keyword | T2 signal intensity | - |
dc.contributor.alternativeName | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.contributor.affiliatedAuthor | 김민정 | - |
dc.contributor.affiliatedAuthor | 김은경 | - |
dc.contributor.affiliatedAuthor | 문희정 | - |
dc.contributor.affiliatedAuthor | 윤정현 | - |
dc.citation.volume | 54 | - |
dc.citation.startPage | 176 | - |
dc.citation.endPage | 182 | - |
dc.identifier.bibliographicCitation | MAGNETIC RESONANCE IMAGING, Vol.54 : 176-182, 2018 | - |
dc.identifier.rimsid | 57882 | - |
dc.type.rims | ART | - |
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