Cited 47 times in
TNF-α-Induced YAP/TAZ Activity Mediates Leukocyte-Endothelial Adhesion by Regulating VCAM1 Expression in Endothelial Cells
DC Field | Value | Language |
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dc.contributor.author | 허지회 | - |
dc.contributor.author | 최현정 | - |
dc.contributor.author | 김병모 | - |
dc.contributor.author | 서미란 | - |
dc.date.accessioned | 2019-01-10T16:40:29Z | - |
dc.date.available | 2019-01-10T16:40:29Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/166586 | - |
dc.description.abstract | YAP/TAZ, a transcriptional co-activator of Hippo pathway, has emerged as a central player in vessel homeostasis such as sprouting angiogenesis and vascular barrier stabilization, during development. However, the role of YAP/TAZ in pathological angiogenesis remains unclear. Here, we demonstrated that YAP/TAZ is a critical mediator in leukocyte-endothelial adhesion induced by the vascular inflammatory cytokine TNF-α. YAP/TAZ was dephosphorylated, translocated from the cytosol to the nucleus, and activated by TNF-α in endothelial cells. A specific inhibitor of Rho GTPases suppressed the TNF-α-induced dephosphorylation of YAP. Knockdown of YAP/TAZ using siRNA significantly reduced the expression of the leukocyte adhesion molecule VCAM1 induced by TNF-α. The adhesion of monocytes to endothelial cells was also markedly reduced by YAP/TAZ silencing. However, knockdown of YAP/TAZ did not affect TNF-α-induced NF-κB signaling. Overall, these results suggest that YAP/TAZ plays critical roles in regulating TNF-α-induced endothelial cell adhesive properties without affecting the NF-κB pathway, and implicate YAP/TAZ as a potential therapeutic target for treating inflammatory vascular diseases. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.publisher | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | TNF-α-Induced YAP/TAZ Activity Mediates Leukocyte-Endothelial Adhesion by Regulating VCAM1 Expression in Endothelial Cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학교실) | - |
dc.contributor.googleauthor | Hyun-Jung Choi | - |
dc.contributor.googleauthor | Na-Eun Kim | - |
dc.contributor.googleauthor | Byeong Mo Kim | - |
dc.contributor.googleauthor | Miran Seo | - |
dc.contributor.googleauthor | Ji Hoe Heo | - |
dc.identifier.doi | 10.3390/ijms19113428 | - |
dc.contributor.localId | A04369 | - |
dc.contributor.localId | A04211 | - |
dc.contributor.localId | A00497 | - |
dc.contributor.localId | A01876 | - |
dc.relation.journalcode | J01133 | - |
dc.identifier.eissn | 1422-0067 | - |
dc.identifier.pmid | 30388809 | - |
dc.subject.keyword | ICAM1 | - |
dc.subject.keyword | NF-κB | - |
dc.subject.keyword | Rho GTPase | - |
dc.subject.keyword | TNF-α | - |
dc.subject.keyword | VCAM1 | - |
dc.subject.keyword | YAP/TAZ | - |
dc.subject.keyword | endothelial cells | - |
dc.contributor.alternativeName | Heo, Ji Hoe | - |
dc.contributor.affiliatedAuthor | 허지회 | - |
dc.contributor.affiliatedAuthor | 최현정 | - |
dc.contributor.affiliatedAuthor | 김병모 | - |
dc.contributor.affiliatedAuthor | 서미란 | - |
dc.citation.volume | 19 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | E3428 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.19(11) : E3428, 2018 | - |
dc.identifier.rimsid | 60324 | - |
dc.type.rims | ART | - |
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