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The Implications of Several Forms of Programmed Necrosis for Cancer Therapy

Authors
 Byeong Mo Kim 
Citation
 Journal of Cancer Science & Therapy, Vol.9 : 630-635, 2017 
Journal Title
Journal of Cancer Science & Therapy
ISSN
 1948-5956 
Issue Date
2017
Keywords
Non-apoptotic or non-autophagic programmed cell death ; Programmed necrosis ; Necroptosis ; Parthanato s ; Pyroptosis ; Ferroptosis ; Cancer treatment
Abstract
The dogma that apoptosis and autophagy are the sole forms of Programmed Cell Death (PCD) is no longer accepted, due to the recent discovery of programmed necrosis, a non-apoptotic, non-autophagic form of PCD. Necroptosis, parthanatos, pyroptosis, and ferroptosis are all forms of programmed necrosis, as these types of cell death dismantle the cell in an ordered fashion that is distinctly different from apoptosis or autophagy. Several key cellular mediators and events in these types of PCD have been discovered. Here, we discuss the basic characteristics, molecular pathways, and possible implications of these lesser-known types of PCD in cancer treatment modalities such as chemotherapy and radiotherapy. Because resistance to apoptosis is often responsible for cancer treatment failures, novel therapeutic strategies that can activate alternative cell death programs have great appeal. Understanding the underlying mechanisms of these types of PCD may facilitate the development of diverse therapeutic strategies, particularly against apoptosis-resistant cancers.
Files in This Item:
T201704817.pdf Download
DOI
10.4172/1948- 5956.1000484
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
Yonsei Authors
Kim, Byeong Mo(김병모) ORCID logo https://orcid.org/0000-0002-0582-3132
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/166583
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