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Optical coherence tomography findings predictive of response to treatment in diabetic macular edema

Authors
 Young Joo Cho  ;  Dong Hyun Lee  ;  Min Kim 
Citation
 Journal of International Medical Research, Vol.46(11) : 4455-4464, 2018 
Journal Title
 Journal of International Medical Research 
ISSN
 0300-0605 
Issue Date
2018
Keywords
Diabetic macular edema ; diabetic retinopathy ; edema ; intravitreal bevacizumab ; optical coherence tomography ; posterior sub-tenon triamcinolone ; retina ; serous retinal detachment
Abstract
OBJECTIVE: To evaluate the short-term efficacy of intravitreal bevacizumab (IVB) and posterior sub-tenon triamcinolone injections (PSTI) on the basis of spectral-domain optical coherence tomography (SD-OCT) patterns in diabetic macular edema (DME). METHODS: We retrospectively reviewed 73 eyes of 73 patients with DME. Based on the presence of serous retinal detachment (SRD), eyes were categorized into two groups, and either IVB or PSTI treatment was performed. Central macular thickness (CMT) and the degree of SRD were assessed preoperatively and 1 month postoperatively. The severity of intraretinal edema was approximated based on the distance from the external limiting membrane to the internal limiting membrane. RESULTS: In eyes with SRD, reduction of SRD was greater with IVB than with PSTI. Moreover, reduction of intraretinal edema was greater with PSTI than with IVB. In eyes without SRD, PSTI achieved greater CMT reduction, compared with IVB. CONCLUSIONS: In DME patients with SRD, IVB achieved greater reduction of SRD, compared with PSTI; however, intraretinal edema responded more favorably to PSTI, regardless of the presence of SRD. Our results suggest that the classification of DME based on OCT findings may be useful to predict responses to IVB or PSTI treatments.
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DOI
10.1177/0300060518798503
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
김민(Kim, Min) ORCID logo https://orcid.org/0000-0003-1873-6959
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/166562
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