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Cerebrospinal Fluid Biomarkers for the Diagnosis of Alzheimer Disease in South Korea

Authors
 Sun Ah Park  ;  Won Seok Chae  ;  Hyeong Jun Kim  ;  Ho Sik Shin  ;  Saeromi Kim  ;  Ji Young Im  ;  Sang Il Ahn  ;  Kyoung Dae Min  ;  Soo Jae Yim  ;  Byoung Seok Ye  ;  Sang Won Seo  ;  Jee Hyang Jeong  ;  Kyung Won Park  ;  Seong Hye Choi  ;  Duk L. Na 
Citation
 ALZHEIMER DISEASE & ASSOCIATED DISORDERS, Vol.31(1) : 13-18, 2017 
Journal Title
 ALZHEIMER DISEASE & ASSOCIATED DISORDERS 
ISSN
 0893-0341 
Issue Date
2017
MeSH
Alzheimer Disease/diagnosis* ; Amyloid beta-Peptides/cerebrospinal fluid ; Biomarkers/cerebrospinal fluid* ; Cognition Disorders/diagnosis* ; Enzyme-Linked Immunosorbent Assay/methods ; Female ; Humans ; Male ; Middle Aged ; Republic of Korea ; tau Proteins/cerebrospinal fluid
Abstract
Laboratory-specific reference values for cerebrospinal fluid (CSF) Alzheimer disease (AD) biomarkers are necessary. Our objective was to apply well-known CSF biomarkers and redetermine their diagnostic cutoff values for AD in South Korea. CSF samples from matched control subjects (n=71), patients with AD dementia (ADD, n=76), and other neurological disorders with cognitive decline (OND, n=47) were obtained from 6 Korean dementia clinics according to a standardized protocol. CSF biomarker concentrations were measured using enzyme-linked immunosorbent assay. CSF biomarkers differed significantly between the ADD and control groups (P<0.001 for all), and between the ADD and OND groups (P<0.001 for all). The areas under the curve in differentiation of ADD from control subjects were 0.97 for Aβ42, 0.93 for total tau (tTau), 0.86 for pTau, and 0.99 for both tTau/Aβ42 and pTau/Aβ42 ratios. Our revised cutoff value for Aβ42 was higher than our previous one, whereas the values for the Tau proteins were similar. The tTau/Aβ42 ratio had the highest accuracy, 97%. Our findings highlight the usefulness of CSF AD biomarkers in South Korea, and the necessity of continually testing the reliability of cutoff values.
Files in This Item:
T999901440.pdf Download
DOI
10.1097/WAD.0000000000000184
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Ye, Byoung Seok(예병석) ORCID logo https://orcid.org/0000-0003-0187-8440
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/166125
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