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Cerebrospinal Fluid Biomarkers for the Diagnosis of Alzheimer Disease in South Korea

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dc.contributor.author예병석-
dc.date.accessioned2018-12-12T03:45:28Z-
dc.date.available2018-12-12T03:45:28Z-
dc.date.issued2017-
dc.identifier.issn0893-0341-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/166125-
dc.description.abstractLaboratory-specific reference values for cerebrospinal fluid (CSF) Alzheimer disease (AD) biomarkers are necessary. Our objective was to apply well-known CSF biomarkers and redetermine their diagnostic cutoff values for AD in South Korea. CSF samples from matched control subjects (n=71), patients with AD dementia (ADD, n=76), and other neurological disorders with cognitive decline (OND, n=47) were obtained from 6 Korean dementia clinics according to a standardized protocol. CSF biomarker concentrations were measured using enzyme-linked immunosorbent assay. CSF biomarkers differed significantly between the ADD and control groups (P<0.001 for all), and between the ADD and OND groups (P<0.001 for all). The areas under the curve in differentiation of ADD from control subjects were 0.97 for Aβ42, 0.93 for total tau (tTau), 0.86 for pTau, and 0.99 for both tTau/Aβ42 and pTau/Aβ42 ratios. Our revised cutoff value for Aβ42 was higher than our previous one, whereas the values for the Tau proteins were similar. The tTau/Aβ42 ratio had the highest accuracy, 97%. Our findings highlight the usefulness of CSF AD biomarkers in South Korea, and the necessity of continually testing the reliability of cutoff values.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfALZHEIMER DISEASE & ASSOCIATED DISORDERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAlzheimer Disease/diagnosis*-
dc.subject.MESHAmyloid beta-Peptides/cerebrospinal fluid-
dc.subject.MESHBiomarkers/cerebrospinal fluid*-
dc.subject.MESHCognition Disorders/diagnosis*-
dc.subject.MESHEnzyme-Linked Immunosorbent Assay/methods-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHtau Proteins/cerebrospinal fluid-
dc.titleCerebrospinal Fluid Biomarkers for the Diagnosis of Alzheimer Disease in South Korea-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.googleauthorSun Ah Park-
dc.contributor.googleauthorWon Seok Chae-
dc.contributor.googleauthorHyeong Jun Kim-
dc.contributor.googleauthorHo Sik Shin-
dc.contributor.googleauthorSaeromi Kim-
dc.contributor.googleauthorJi Young Im-
dc.contributor.googleauthorSang Il Ahn-
dc.contributor.googleauthorKyoung Dae Min-
dc.contributor.googleauthorSoo Jae Yim-
dc.contributor.googleauthorByoung Seok Ye-
dc.contributor.googleauthorSang Won Seo-
dc.contributor.googleauthorJee Hyang Jeong-
dc.contributor.googleauthorKyung Won Park-
dc.contributor.googleauthorSeong Hye Choi-
dc.contributor.googleauthorDuk L. Na-
dc.identifier.doi10.1097/WAD.0000000000000184-
dc.contributor.localIdA04603-
dc.relation.journalcodeJ00067-
dc.identifier.eissn1546-4156-
dc.identifier.pmid28030437-
dc.contributor.alternativeNameYe, Byoung Seok-
dc.contributor.affiliatedAuthor예병석-
dc.citation.volume31-
dc.citation.number1-
dc.citation.startPage13-
dc.citation.endPage18-
dc.identifier.bibliographicCitationALZHEIMER DISEASE & ASSOCIATED DISORDERS, Vol.31(1) : 13-18, 2017-
dc.identifier.rimsid58388-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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