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Levels and Temporal Trends (2002–2008) of Dioxins in the Blood of Urban Dwellers in Korea

 Yang, Ji Yeon  ;  Shin, Dong Chun  ;  Kim, Ho Hyun  ;  Chang, Yoon Seok  ;  Lim, Young Wook 
 EPIDEMIOLOGY, Vol.1 : S233-S234, 2011 
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Background/Aims: In Korea, the number of municipal and hazardous waste incinerators, both of which emit dioxin-like compounds, has increased since 1980. Therefore, the human health risks caused by dioxin have become a matter of increasing public concern. We measured the recent background serum levels of exposure to PCDD/Fs and analyzed trend of dioxin levels in the blood of urban dwellers in Korea between 2002 and 2008.

Methods: Blood samples were obtained between 2002 and 2008 from 278 volunteers. All participants were nonsmokers and were 21 to 75 years of age, who had lived in the urban area for at least 5 years. Quantitative assessment of the levels of dioxin compounds (17 congeners) in the serum was performed using high-resolution gas chromatography/high-resolution mass spectrometry according to the US Environmental Protection Agency 1613 method. Toxic equivalents (TEQ) were calculated using the TEQ factors established by World Health Organization in 2005.

Results: The means and standard deviations of dioxins were 10.66 ± 7.34 in 2002, 8.20 ± 6.07 in 2003, 10.01 ± 7.56 in 2004, 10.12 ± 5.48 in 2006, 10.66 ± 5.64 in 2007, and 10.97 ± 4.71 pg-TEQ05/g lipid in 2008. The percent contribution of lower chlorinated PCDD increased but those of OCDD and PeCDF decreased. In all years, age was positively associated with blood levels of dioxins, whereas the blood levels of dioxins did not significantly change over 6 years. Between 2002 and 2008, if the subjects' BMI was greater than 25 in the older (40+) age group, the dioxin levels of subjects who had higher BMIs (≥25) declined less than that of the older subjects with lower BMIs (<25).

Conclusion: Although the dioxin levels in blood did not decline over time from 2002 to 2008, the serum levels of dioxins were significantly correlated with age and BMI. The significant time-BMI interaction of serum dioxin levels indicates that body fat affects the reduction rate of the dioxins concentration in blood.
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Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Kim, Ho Hyen(김호현)
Shin, Dong Chun(신동천) ORCID logo https://orcid.org/0000-0003-4252-2280
Yang, Ji Yeon(양지연)
Lim, Young Wook(임영욱) ORCID logo https://orcid.org/0000-0001-8845-2850
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