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Parvovirus B19-induced pure red cell aplasia in a liver transplant recipient

 Eun Young Lee  ;  Yonggeun Cho  ;  Sang-Guk Lee  ;  Jaewoo Song 
 Korean Journal of Laboratory Medicine, Vol.30(6) : 591-594, 2010 
Journal Title
 Korean Journal of Laboratory Medicine 
Issue Date
Blood Transfusion ; Bone Marrow/pathology ; Carcinoma ; Hepatocellular/etiology ; Carcinoma ; Hepatocellular/therapy ; DNA ; Viral/analysis ; Female ; Hepatitis C/complications ; Hepatitis C/diagnosis ; Humans ; Immunocompromised Host ; Immunoglobulins/therapeutic use ; Liver Neoplasms/etiology ; Liver Neoplasms/therapy ; Liver Transplantation ; Middle Aged ; Parvoviridae Infections/complications ; Parvoviridae Infections/diagnosis* ; Parvovirus B19 ; Human*/genetics ; Red-Cell Aplasia ; Pure/diagnosis* ; Red-Cell Aplasia ; Pure/therapy ; Red-Cell Aplasia ; Pure/virology
Parvovirus B19 infection is known to cause chronic anemia in immunocompromised hosts ; including organ transplant recipients. We report the first case of liver transplant recipient with parvovirus B19-induced pure red cell aplasia in Korea. A 57-yr-old female patient with hepatocellular carcinoma due to hepatitis C virus received a liver transplantation. Two months later ; anemia developed and she received periodic red blood cell transfusions. However ; chronic anemia persisted and bone marrow examination was performed 8 months after transplantation. Bone marrow aspiration smears showed markedly reduced erythroid precursors with atypical giant pronormoblasts and nuclear remnants with viral inclusions ; and characteristic lantern cells were observed in biopsy sections. In addition ; parvovirus B19 DNA PCR was positive. She was diagnosed as parvovirus B19-induced pure red cell aplasia and her anemia was improved following intravenous immunoglobulin therapy.
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1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Sang-Guk(이상국) ORCID logo https://orcid.org/0000-0003-3862-3660
Cho, Yonggeun(조용근) ORCID logo https://orcid.org/0000-0003-1946-4318
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