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Differential impact of white matter hyperintensities on long-term outcomes in ischemic stroke patients with large artery atherosclerosis

DC FieldValueLanguage
dc.contributor.author김영대-
dc.contributor.author김현창-
dc.contributor.author남효석-
dc.contributor.author박형종-
dc.contributor.author허지회-
dc.date.accessioned2018-11-29T16:55:56Z-
dc.date.available2018-11-29T16:55:56Z-
dc.date.issued2017-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/165924-
dc.description.abstractBACKGROUND: The presence of white matter hyperintensity (WMH) is related to poor long-term outcomes in stroke patients. However, the long-term outcome is unknown in patients with both large artery atherosclerosis (LAA) and WMH. METHODS: We investigated the impact of WMH on long-term outcome in patients with LAA. Consecutive patients in a prospective stroke registry were included. Patients were followed for a median of 7.7 years (interquartile range, 5.6-9.7). The degree of WMH was assessed by Fazekas grade on fluid-attenuated inversion recovery images. Total WMH burden was calculated by summation of Fazekas scores in periventricular and deep white matter. Severe WMH was defined as total burden score ≥ 3. RESULTS: Among 2529 patients, 639 patients (25.3%) were classified with the LAA subtype. After applying exclusion criteria, the data from 538 patients were analyzed. The mean patient age was 65.7 ± 10.3 years. Severe WMHs were found in 243 patients (45.2%). During follow-up, 200 patients (37.2%) died. Cox regression analysis showed that LAA patients with severe WMH had a 1.50-fold (95% CI, 1.12-2.00, p = 0.007) higher death rate compared to those without. In the older age group (≥65 years), Cox regression revealed that patients with severe WMH had a 1.75-fold (95% CI, 1.15-2.65, p = 0.008) higher 5-year death rate, whereas the younger age group did not have this association. CONCLUSION: The degree of WMH might be a surrogate marker for long-term outcome in patients with LAA. Atherosclerotic burdens in both small and large arteries might impact long-term prognosis in ischemic stroke patients.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherPublic Library of Science-
dc.relation.isPartOfPLoS One-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleDifferential impact of white matter hyperintensities on long-term outcomes in ischemic stroke patients with large artery atherosclerosis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.googleauthorMinyoul Baik-
dc.contributor.googleauthorKyoungsub Kim-
dc.contributor.googleauthorJoonsang Yoo-
dc.contributor.googleauthorHyeon Chang Kim-
dc.contributor.googleauthorSeong Ho Jeong-
dc.contributor.googleauthorKi Hoon Kim-
dc.contributor.googleauthorHyung Jong Park-
dc.contributor.googleauthorYoung Dae Kim-
dc.contributor.googleauthorJi Hoe Heo-
dc.contributor.googleauthorHyo Suk Nam-
dc.identifier.doi10.1371/journal.pone.0189611-
dc.contributor.localIdA00702-
dc.contributor.localIdA01142-
dc.contributor.localIdA01142-
dc.contributor.localIdA01273-
dc.contributor.localIdA01273-
dc.contributor.localIdA05600-
dc.contributor.localIdA05600-
dc.contributor.localIdA04369-
dc.contributor.localIdA04369-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid29232701-
dc.contributor.alternativeNameKim, Young Dae-
dc.contributor.affiliatedAuthor김영대-
dc.contributor.affiliatedAuthor김현창-
dc.contributor.affiliatedAuthor김현창-
dc.contributor.affiliatedAuthor남효석-
dc.contributor.affiliatedAuthor남효석-
dc.contributor.affiliatedAuthor박형종-
dc.contributor.affiliatedAuthor박형종-
dc.contributor.affiliatedAuthor허지회-
dc.contributor.affiliatedAuthor허지회-
dc.citation.volume12-
dc.citation.number12-
dc.citation.startPagee0189611-
dc.identifier.bibliographicCitationPLoS One, Vol.12(12) : e0189611, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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