Cited 5 times in
Differential impact of white matter hyperintensities on long-term outcomes in ischemic stroke patients with large artery atherosclerosis
DC Field | Value | Language |
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dc.contributor.author | 김영대 | - |
dc.contributor.author | 김현창 | - |
dc.contributor.author | 남효석 | - |
dc.contributor.author | 박형종 | - |
dc.contributor.author | 허지회 | - |
dc.date.accessioned | 2018-11-29T16:55:56Z | - |
dc.date.available | 2018-11-29T16:55:56Z | - |
dc.date.issued | 2017 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/165924 | - |
dc.description.abstract | BACKGROUND: The presence of white matter hyperintensity (WMH) is related to poor long-term outcomes in stroke patients. However, the long-term outcome is unknown in patients with both large artery atherosclerosis (LAA) and WMH. METHODS: We investigated the impact of WMH on long-term outcome in patients with LAA. Consecutive patients in a prospective stroke registry were included. Patients were followed for a median of 7.7 years (interquartile range, 5.6-9.7). The degree of WMH was assessed by Fazekas grade on fluid-attenuated inversion recovery images. Total WMH burden was calculated by summation of Fazekas scores in periventricular and deep white matter. Severe WMH was defined as total burden score ≥ 3. RESULTS: Among 2529 patients, 639 patients (25.3%) were classified with the LAA subtype. After applying exclusion criteria, the data from 538 patients were analyzed. The mean patient age was 65.7 ± 10.3 years. Severe WMHs were found in 243 patients (45.2%). During follow-up, 200 patients (37.2%) died. Cox regression analysis showed that LAA patients with severe WMH had a 1.50-fold (95% CI, 1.12-2.00, p = 0.007) higher death rate compared to those without. In the older age group (≥65 years), Cox regression revealed that patients with severe WMH had a 1.75-fold (95% CI, 1.15-2.65, p = 0.008) higher 5-year death rate, whereas the younger age group did not have this association. CONCLUSION: The degree of WMH might be a surrogate marker for long-term outcome in patients with LAA. Atherosclerotic burdens in both small and large arteries might impact long-term prognosis in ischemic stroke patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Public Library of Science | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Differential impact of white matter hyperintensities on long-term outcomes in ischemic stroke patients with large artery atherosclerosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학교실) | - |
dc.contributor.googleauthor | Minyoul Baik | - |
dc.contributor.googleauthor | Kyoungsub Kim | - |
dc.contributor.googleauthor | Joonsang Yoo | - |
dc.contributor.googleauthor | Hyeon Chang Kim | - |
dc.contributor.googleauthor | Seong Ho Jeong | - |
dc.contributor.googleauthor | Ki Hoon Kim | - |
dc.contributor.googleauthor | Hyung Jong Park | - |
dc.contributor.googleauthor | Young Dae Kim | - |
dc.contributor.googleauthor | Ji Hoe Heo | - |
dc.contributor.googleauthor | Hyo Suk Nam | - |
dc.identifier.doi | 10.1371/journal.pone.0189611 | - |
dc.contributor.localId | A00702 | - |
dc.contributor.localId | A01142 | - |
dc.contributor.localId | A01273 | - |
dc.contributor.localId | A05600 | - |
dc.contributor.localId | A04369 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 29232701 | - |
dc.contributor.alternativeName | Kim, Young Dae | - |
dc.contributor.affiliatedAuthor | 김영대 | - |
dc.contributor.affiliatedAuthor | 김현창 | - |
dc.contributor.affiliatedAuthor | 남효석 | - |
dc.contributor.affiliatedAuthor | 박형종 | - |
dc.contributor.affiliatedAuthor | 허지회 | - |
dc.citation.volume | 12 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | e0189611 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.12(12) : e0189611, 2017 | - |
dc.identifier.rimsid | 60309 | - |
dc.type.rims | ART | - |
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