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Temporal pole morphology and psychopathology in males with schizophrenia

 Benedicto Crespo-Facorroa  ;  Peggy C. Nopoulosa  ;  Eran Chemerinskia  ;  Jae-Jin Kim  ;  Nancy C. Andreasena  ;  Vincent Magnotta 
 Psychiatry Research, Vol.132(2) : 107-115, 2004 
Journal Title
 Psychiatry Research 
Issue Date
Adult ; Diagnostic and Statistical Manual of Mental Disorders ; Humans ; Limbic System/abnormalities ; Limbic System/physiopathology ; Magnetic Resonance Imaging ; Male ; Reproducibility of Results ; Schizophrenia/diagnosis ; Schizophrenia/physiopathology* ; Schizophrenic Psychology* ; Temporal Lobe/abnormalities ; Temporal Lobe/physiopathology*
A dysfunction of the paralimbic system has been implicated in the pathophysiology of schizophrenia. The temporal pole (TP) is a relevant component of the paralimbic circuit. Functional and structural imaging studies have shown circumscribed abnormalities in the TP. Subjects were 30 controls and 30 schizophrenia patients. Cortical surface size and gray matter volume of the TP were accurately measured to explore the morphology of the TP cortex and the relationship of TP measures to clinical variables in patients with schizophrenia. Correlations between structural measures and clinical dimensions, duration of illness, and cumulative neuroleptic exposure were determined. Neither macroscopic abnormalities in the TP nor differences in the pattern of asymmetry were demonstrated. The TP volume was correlated negatively to the psychotic and disorganized dimension scores. No other significant correlations were found. No morphological abnormalities in the TP were found in patients with schizophrenia. Interestingly, a reduction in the TP volume, a higher-order multimodal association cortex, was associated with the severity of disorganized and psychotic symptoms
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
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