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Mutations in the Spliceosomal Machinery Genes SRSF2, U2AF1, and ZRSR2 and Response to Decitabine in Myelodysplastic Syndrome.

Authors
 JUNG YONG HONG  ;  JA-YOUNG SEO  ;  SUN-HEE KIM  ;  HYUN AE JUNG  ;  SILVIA PARK  ;  KIHYUN KIM  ;  CHUL WON JUNG  ;  JIN SEOK KIM  ;  JOON SEONG PARK  ;  HEE-JIN KIM  ;  JUN HO JANG 
Citation
 Anticancer Research, Vol.35(5) : 3081-3089, 2015 
Journal Title
 Anticancer Research 
ISSN
 0250-7005 
Issue Date
2015
MeSH
Adult ; Aged ; Aged, 80 and over ; Azacitidine/administration & dosage ; Azacitidine/analogs & derivatives* ; Female ; Humans ; Male ; Middle Aged ; Mutation ; Myelodysplastic Syndromes/drug therapy ; Myelodysplastic Syndromes/genetics* ; Myelodysplastic Syndromes/pathology ; Nuclear Proteins/genetics* ; Prognosis ; RNA Splicing/genetics ; Ribonucleoproteins/genetics* ; Serine-Arginine Splicing Factors ; Spliceosomes/drug effects ; Spliceosomes/genetics ; Splicing Factor U2AF ; Treatment Outcome
Keywords
Myelodysplastic syndrome ; SRSF2 ; U2AF1 ; ZRSR2 ; decitabine
Abstract
BACKGROUND: Hypomethylating agents, such as azacitidine and decitabine, now constitute one of the mainstays of myelodysplastic syndrome (MDS) treatment. In recent years, novel recurrent mutations in multiple genes encoding RNA spliceosomal machinery (SRSF2, U2AF1, ZRSR2, SF3B1) were revealed. However, the clinical impact of these mutations on the outcomes of treatment of MDS patients with hypomethylating agents has not been described. PATIENTS AND METHODS: A total of 58 de novo MDS patients were included in the study who had received first-line decitabine treatment. Polymerase chain reaction (PCR) followed by direct sequencing analyses was performed for the spliceosomal machinery genes including SRSF2, U2AF1 and ZRSR2. RESULTS: In the present analysis of 58 Korean MDS patients, mutations in the splicing machinery genes SRSF2, U2AF1 and ZRSR2 were detected in 5 (8.6%), 10 (17.2%) and 6 (10.3%) patients, respectively, and the incidence of SRSF2 mutation was lower than those of previous series. The overall response rates (ORRs) including complete remission (CR), partial response (PR), and marrow CR (mCR) were 42.9% in the spliceosome wild-type (WT) group and 46.7% in the spliceosome-mutated group (p>0.999). The median OS was 22.0 months in the spliceosome-WT group and 15.9 months in the spliceosome-mutated group (p=0.267) CONCLUSION: This study firstly reports the impact of mutations of the spliceosomal machinery genes on the outcomes of decitabine treatment in MDS. The mutational status of the SRSF2, U2AF1 and ZRSR2 did not affect the response rate or survival in MDS patients who had received first-line decitabine treatment. Further studies are needed to confirm the prognostic relevance of spliceosome mutations to the clinical outcomes of treatment with hypomethylating agents.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jin Seok(김진석) ORCID logo https://orcid.org/0000-0001-8986-8436
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165809
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