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Clinical outcome and prognosis of patients with primary sinonasal tract diffuse large B-cell lymphoma treated with rituximab-cyclophosphamide, doxorubicin, vincristine and prednisone chemotherapy: a study by the Consortium for Improving Survival of Lymphoma.

Authors
 Gyeong-Won Lee  ;  Se-Il Go  ;  Seok-Hyun Kim  ;  Junshik Hong  ;  Yu Ri Kim  ;  Sukjoong Oh  ;  Sung-Yong Kim  ;  Young Rok Do  ;  Hyewon Lee  ;  Soon Il Lee  ;  Sung Hwa Bae  ;  Sung Yong Oh  ;  Moo Kon Song  ;  Won-Sik Lee  ;  Bohee Lee  ;  Jin Seok Kim  ;  Min Kyoung Kim  ;  Hye Jin Kang  ;  Jae-Sook Ahn  ;  Ho-Young Yhim  ;  Hyo Jung Kim  ;  Seok Jin Kim  ;  Won Seog Kim 
Citation
 LEUKEMIA & LYMPHOMA, Vol.56(4) : 1020-1026, 2015 
Journal Title
 LEUKEMIA & LYMPHOMA 
ISSN
 1042-8194 
Issue Date
2015
MeSH
Adult ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use* ; Cyclophosphamide/administration & dosage ; Disease-Free Survival ; Doxorubicin/administration & dosage ; Female ; Humans ; Lymphoma, Large B-Cell, Diffuse/drug therapy* ; Lymphoma, Large B-Cell, Diffuse/pathology ; Male ; Middle Aged ; Multivariate Analysis ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Paranasal Sinus Neoplasms/drug therapy* ; Prednisone/administration & dosage ; Prognosis ; Rituximab/administration & dosage ; Treatment Outcome ; Vincristine/administration & dosage
Keywords
Diffuse large cell lymphomas ; nasal cavities ; paranasal sinus ; rituximab
Abstract
We evaluated the clinical outcomes and relapse patterns of 80 patients with primary sinonasal tract diffuse large B-cell lymphoma (SN-DLBCL) treated with rituximab-cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP) chemotherapy at 22 institutions. A total of 59 (73.8%) patients received R-CHOP chemotherapy alone, whereas 21 (26.3%) were treated with R-CHOP followed by involved field radiotherapy (IFRT). In 73 patients with Ann Arbor stage I-II disease, no significant difference was found in the response rate or overall survival (OS) between R-CHOP alone (n = 52) and R-CHOP followed by IFRT (n = 21). Among 11 relapsed patients in this study, the most common pattern of relapse was local (n = 8, 11.8%), whereas central nervous system (CNS) relapse was observed in only one (1.9%) patient. These results suggest that patients with primary SN-DLBCL treated with R-CHOP have a relatively low CNS relapse rate and better OS compared to previous studies before the introduction of R.
Full Text
https://www.tandfonline.com/doi/full/10.3109/10428194.2014.946027
DOI
10.3109/10428194.2014.946027
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jin Seok(김진석) ORCID logo https://orcid.org/0000-0001-8986-8436
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165806
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