췌장낭종이 췌장암의 발생위험을 증가시키는가에 대한 연구: 40세 이상의 한국인 대상으로

Abstract

Background: Whether pancreatic cysts such as mucinous cystic neoplasm and intraductal papillary mucinous neoplasm have malignant potential is known. However, whether patients with benign pancreatic cysts have a higher risk of pancreatic cancer (PaCa) has not been established yet. Methods: We evaluated data from the National Health Insurance Service-National Sample Cohort (2002–2006) of the Korean National Health Insurance Service. Patients with pancreatic cysts detected on computed tomography/magnetic resonance imaging were identified using the Korean Classification of Diseases, 6th Edition. Patients aged >40 years with and those without pancreatic cystic lesions were followed up until 2010 (389,777 patients). Results: During the study period, PaCa was diagnosed in 2 of 71 patients with pancreatic cysts and in 1,605 of 389,706 patients without pancreatic cyst. The incidence rates of PaCa were 2.82% and 0.41%, respectively. The hazard ratio of PaCa in all the patients with cysts was 9.839 (95% confidence interval, 2.461–39.332; P=0.0012) when compared with the rest of the patients without cysts. Conclusion: Patients aged >40 years with pancreatic cysts have a significantly higher risk of PaCa.