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Prevalence of human papillomavirus infection and RAS mutation in sporadic keratoacanthoma

Authors
 Mi Ryung Roh  ;  Jee Hung Kim  ;  Sang Hee Lee  ;  Seung Joon Oh  ;  Kyu Hyun Park  ;  Kee Yang Chung  ;  Sun Young Rha 
Citation
 International Journal of Dermatology, Vol.54(11) : e453-e457, 2015 
Journal Title
 International Journal of Dermatology 
ISSN
 0011-9059 
Issue Date
2015
MeSH
Adult ; Aged ; Aged, 80 and over ; DNA, Viral/analysis ; Female ; GTP Phosphohydrolases/genetics* ; Humans ; Keratoacanthoma/genetics* ; Keratoacanthoma/virology* ; Male ; Membrane Proteins/genetics* ; Middle Aged ; Mutation ; Papillomavirus Infections/complications* ; Proto-Oncogene Proteins p21(ras)/genetics* ; Skin Aging/genetics
Abstract
BACKGROUND: RAS gene activation and its association with human papillomavirus (HPV) infection have been extensively studied in various cancers. However, the correlation between RAS mutations and HPV in keratoacanthoma (KA) has not yet been investigated. METHODS: Detection of HPV DNA was performed by nested polymerase chain reaction in 28 KA specimens. Molecular analysis was also performed to identify oncogenic mutations (HRAS, KRAS, NRAS). Statistical analyses were performed using the Fisher's exact tests. RESULTS: HPV DNA was detected in eight (28.6%) of the 28 samples, and RAS mutations were detected in eight (28.6%). Six samples had an HRAS mutation, and two showed the NRAS mutation. The presence of an RAS mutation was significantly correlated with a history of chronic sun damage (P = 0.005). However, no significant correlation was observed between HPV infection and RAS mutation. CONCLUSIONS: Our findings suggest that mutational activation of the RAS gene is a common event in KA. However, RAS oncogene activation and HPV infection seem to represent two independent factors in the development of KA.
Full Text
https://onlinelibrary.wiley.com/doi/epdf/10.1111/ijd.12669
DOI
10.1111/ijd.12669
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김지형(Kim, Jee Hung) ORCID logo https://orcid.org/0000-0002-9044-8540
노미령(Roh, Mi Ryung) ORCID logo https://orcid.org/0000-0002-6285-2490
라선영(Rha, Sun Young)
이상희(Lee, Sang Hee)
정기양(Chung, Kee Yang)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165660
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