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Prevalence of human papillomavirus infection and RAS mutation in sporadic keratoacanthoma

 Mi Ryung Roh  ;  Jee Hung Kim  ;  Sang Hee Lee  ;  Seung Joon Oh  ;  Kyu Hyun Park  ;  Kee Yang Chung  ;  Sun Young Rha 
 International Journal of Dermatology, Vol.54(11) : e453-e457, 2015 
Journal Title
 International Journal of Dermatology 
Issue Date
Adult ; Aged ; Aged, 80 and over ; Drug Resistance, Multiple, Bacterial ; Female ; Humans ; Male ; Middle Aged ; Republic of Korea ; Retrospective Studies ; Serratia Infections/diagnosis ; Serratia Infections/drug therapy ; Serratia Infections/microbiology* ; Serratia marcescens*/drug effects ; Serratia marcescens*/isolation & purification ; Skin Diseases, Bacterial/diagnosis ; Skin Diseases, Bacterial/drug therapy ; Skin Diseases, Bacterial/microbiology* ; Young Adult
Serratia marcescens ; antimicrobial resistance ; cutaneous infection ; host immune status ; risk factors
BACKGROUND: RAS gene activation and its association with human papillomavirus (HPV) infection have been extensively studied in various cancers. However, the correlation between RAS mutations and HPV in keratoacanthoma (KA) has not yet been investigated. METHODS: Detection of HPV DNA was performed by nested polymerase chain reaction in 28 KA specimens. Molecular analysis was also performed to identify oncogenic mutations (HRAS, KRAS, NRAS). Statistical analyses were performed using the Fisher's exact tests. RESULTS: HPV DNA was detected in eight (28.6%) of the 28 samples, and RAS mutations were detected in eight (28.6%). Six samples had an HRAS mutation, and two showed the NRAS mutation. The presence of an RAS mutation was significantly correlated with a history of chronic sun damage (P = 0.005). However, no significant correlation was observed between HPV infection and RAS mutation. CONCLUSIONS: Our findings suggest that mutational activation of the RAS gene is a common event in KA. However, RAS oncogene activation and HPV infection seem to represent two independent factors in the development of KA.
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1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jee Hung(김지형) ORCID logo https://orcid.org/0000-0002-9044-8540
Roh, Mi Ryung(노미령) ORCID logo https://orcid.org/0000-0002-6285-2490
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
Lee, Sang Hee(이상희)
Chung, Kee Yang(정기양) ORCID logo https://orcid.org/0000-0003-3257-0297
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