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Local excision after neoadjuvant chemoradiation therapy in advanced rectal cancer: a national multicenter analysis

Authors
 Chang Sik Yu  ;  Hae Ran Yun  ;  Eung Jin Shin  ;  Kang Yong Lee  ;  Nam Kyu Kim  ;  Seok-Byung Lim  ;  Seong Taek Oh  ;  Sung-Bum Kang  ;  Won Joon Choi  ;  Woo Yong Lee 
Citation
 AMERICAN JOURNAL OF SURGERY, Vol.206(4) : 482-487, 2013 
Journal Title
 AMERICAN JOURNAL OF SURGERY 
ISSN
 0002-9610 
Issue Date
2013
MeSH
Adult ; Aged ; Aged, 80 and over ; Chemoradiotherapy* ; Female ; Humans ; Male ; Middle Aged ; Neoadjuvant Therapy* ; Neoplasm Metastasis ; Neoplasm Recurrence, Local ; Rectal Neoplasms/mortality ; Rectal Neoplasms/pathology ; Rectal Neoplasms/therapy* ; Rectum/surgery* ; Retrospective Studies
Keywords
Local excision ; Neoadjuvant chemoradiation therapy ; Rectal cancer
Abstract
BACKGROUND: The aim of the current study was to evaluate the clinical availability of local excision (LE) for advanced rectal cancer without lymph node metastasis after neoadjuvant chemoradiation therapy (nCRT) in Korea. METHODS: From June 2000 to October 2009, 40 patients with cT2-3N0M0 rectal cancer underwent nCRT followed by LE according to a retrospective multicenter analysis. RESULTS: Of the 40 patients, 22 were men and 18 were women. Eighteen patients were cT2, and 22 patients were cT3. The median follow-up duration was 38 months. Three patients (7.5%) had morbidity after LE. Four patients (10%) had recurrence (local recurrence [1 patient] and systemic metastasis [3 patients]). The 3-year disease-free survival rate was 85.9%. Only pCR was a recurrence-related prognostic factor (P = .040). CONCLUSIONS: Although the current study was not a randomized controlled study, LE after nCRT in T2-3N0 rectal cancer patients appears to be a safe and effective treatment, especially in pCR patients.
Full Text
https://www.sciencedirect.com/science/article/pii/S0002961013002948
DOI
10.1016/j.amjsurg.2013.01.042
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Nam Kyu(김남규) ORCID logo https://orcid.org/0000-0003-0639-5632
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165599
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