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Role of oxygen free radicals in patients with acute pancreatitis

 Byung Kyu Park  ;  Jae Bock Chung  ;  Jin Heon Lee  ;  Jeong Hun Suh  ;  Seung Woo Park  ;  Si Young Song  ;  Hyeyoung Kim  ;  Kyung Hwan Kim  ;  Jin Kyung Kang 
 WORLD JOURNAL OF GASTROENTEROLOGY, Vol.9(10) : 2266-2269, 2003 
Journal Title
Issue Date
Acute Disease ; Adult ; Aged ; Female ; Humans ; Lipid Peroxides/blood* ; Male ; Middle Aged ; Oxidative Stress* ; Pancreatitis/etiology ; Pancreatitis/metabolism* ; Peroxidase/blood ; Predictive Value of Tests ; Prognosis ; Reactive Oxygen Species/metabolism ; Severity of Illness Index* ; Superoxide Dismutase/blood
AIM: The generation of oxygen free radicals has been implicated in the pathogenesis of experimental pancreatitis. The aim of this study was to determine the role of oxygen free radicals in patients with acute pancreatitis. METHODS: The plasma levels of C-reactive protein (CRP), lipid peroxide (LPO), myeloperoxidase (MPO) and superoxide dismutase (SOD) were measured in 13 patients with acute pancreatitis and 14 healthy volunteers. RESULTS: Among the patients with acute pancreatitis, there were higher plasma levels of LPO and MPO and lower SOD activity in patients with severe pancreatitis than in those with mild pancreatitis. However, there was no significant difference in the serum marker of oxidative stress no matter what the etiology was. The LPO level was especially correlated with the concentration of serum CRP and CT severity index. CONCLUSION: The oxygen free radicals may be closely associated with inflammatory process and the severity of acute pancreatitis. Especially, the concentration of plasma LPO is a meaningful index for determining the severity of the disease
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
Yonsei Authors
Kang, Jin Kyung(강진경)
Kim, Kyung Hwan(김경환)
Park, Byung Kyu(박병규)
Park, Seung Woo(박승우) ORCID logo https://orcid.org/0000-0001-8230-964X
Song, Si Young(송시영) ORCID logo https://orcid.org/0000-0002-1417-4314
Chung, Jae Bock(정재복)
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