0 38

Cited 2 times in

Higher maternal vitamin D concentrations are associated with longer leukocyte telomeres in newborns.

Authors
 Jung‐Ha Kim  ;  Gwang Jun Kim  ;  Donghee Lee  ;  Jae‐Hong Ko  ;  Inja Lim  ;  Hyoweon Bang  ;  Bart W. Koes  ;  Byeongchan Seong  ;  Duk‐Chul Lee 
Citation
 Maternal & Child Nutrition, Vol.14(1) : e12475, 2018 
Journal Title
 Maternal & Child Nutrition 
ISSN
 1740-8695 
Issue Date
2018
MeSH
25-Hydroxyvitamin D 2/blood ; Birth Weight ; Calcifediol/blood ; Cross-Sectional Studies ; Female ; Fetal Blood/cytology ; Fetal Blood/metabolism ; Humans ; Infant, Newborn ; Leukocytes/cytology ; Leukocytes/metabolism ; Leukocytes/pathology* ; Male ; Maternal Nutritional Physiological Phenomena* ; Multivariate Analysis ; Nutritional Status* ; Pregnancy ; Pregnancy Complications/blood ; Pregnancy Complications/epidemiology ; Pregnancy Complications/pathology* ; Pregnancy Complications/physiopathology ; Pregnancy Trimester, Third ; Prevalence ; Republic of Korea/epidemiology ; Severity of Illness Index ; Telomere Shortening* ; Vitamin D/blood* ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/epidemiology ; Vitamin D Deficiency/pathology* ; Vitamin D Deficiency/physiopathology
Keywords
maternal inheritance ; maternal nutrition ; micronutrients ; newborn ; telomere length ; vitamin D
Abstract
Gestational vitamin D insufficiency is related with increased risks of various diseases and poor health outcomes later in life. Telomere length at birth or early in life is known to be a predictor of individual health. Both vitamin D and telomere length are related with various health conditions, and vitamin D concentrations are associated with leukocyte telomere lengths in women. We investigated the association between maternal vitamin D concentrations and newborn leukocyte telomere lengths. This cross-sectional study included 106 healthy pregnant women without adverse obstetric outcomes and their offspring. We examined the maternal age, weight before pregnancy, health behaviours, and nutritional intakes, along with each newborn's sex and birthweight, and we measured maternal height, telomere length, total white blood cell count, and glycosylated haemoglobin as covariates. Pearson's correlation coefficients were calculated to evaluate the relationship between the baseline variables and newborn leukocyte telomere lengths. To confirm that there was an independent association between newborn leukocyte telomere lengths and maternal vitamin D concentrations, we performed a stepwise multiple linear regression analysis. Newborn leukocyte telomere lengths correlated positively with maternal leukocyte telomere lengths (r = .76, p < .01), maternal 25-hydroxyvitamin D concentrations (r = .72, p < .01), maternal energy intakes (r = .22, p = .03), and newborn body weights (r = .51, p < .01). In the multivariate model, newborn leukocyte telomere lengths were associated with maternal vitamin D concentrations (β = .33, p < .01). These findings suggest that the maternal vitamin D concentration during pregnancy may be a significant determinant of the offspring's telomere length
Full Text
https://onlinelibrary.wiley.com/doi/full/10.1111/mcn.12475
DOI
10.1111/mcn.12475
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
이덕철(Lee, Duk Chul) ORCID logo https://orcid.org/0000-0001-9166-1813
Export
RIS (EndNote)
XLS (Excel)
XML
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165571
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse