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Risk of Retinal Vein Occlusion in Patients With End-Stage Renal Disease: A 12-Year, Retrospective, Nationwide Cohort Study in South Korea.

 Kyung Sik Lee  ;  Ki Heon Nam  ;  Dong Wook Kim  ;  Eui Chun Kang  ;  Hyoung Jun Koh 
 Investigative Ophthalmology & Visual Science, Vol.59 : 39-44, 2018 
Journal Title
 Investigative Ophthalmology & Visual Science 
Issue Date
Adult ; Aged ; Female ; Follow-Up Studies ; Forecasting* ; Humans ; Incidence ; Kidney Failure, Chronic/complications* ; Kidney Failure, Chronic/epidemiology ; Male ; Middle Aged ; Propensity Score* ; Republic of Korea/epidemiology ; Retinal Vein Occlusion/diagnosis ; Retinal Vein Occlusion/epidemiology ; Retinal Vein Occlusion/etiology* ; Retrospective Studies
Purpose: The present study aimed to evaluate the risk of retinal vein occlusion (RVO) in Korean patients with end-stage renal disease (ESRD). Methods: In this retrospective, nationwide, propensity score-matched cohort study, subjects were randomly enrolled from the 12-year longitudinal Korean National Health Insurance Service-National Sample Cohort 2002-2013 database comprising 1 million subjects. The ESRD group comprised 988 patients newly diagnosed with ESRD from 2003 onward by washing out data from 2002. The comparison group comprised 4940 (5 for each patient with ESRD) randomly selected propensity score-matched individuals not diagnosed with ESRD. Each sampled patient was tracked until 2013 for RVO development. Multiple conditional Cox regression analysis was performed to compare the risk of RVO between the two groups. Results: The mean follow-up period was 7.37 years. The incidence of RVO was 3.95% in the ESRD group and 2.17% in the comparison group (P = 0.001). ESRD was associated with greater risk of RVO development after adjustment for possible confounders (adjusted hazard ratio [HR], 2.122; 95% confidence interval [CI], 1.396-3.226; P = 0.0004). The 50- to 60-year (adjusted HR, 2.635; 95% CI, 1.100-6.313; P = 0.0297) and 60- to 70-year (adjusted HR, 2.544; 95% CI, 1.059-6.110; P = 0.0368) age groups exhibited higher risk of RVO compared with the <40-year age group. Hyperlipidemia (adjusted HR, 1.670; 95% CI, 1.176-2.371; P = 0.0042) and hypertension (adjusted HR, 1.896; 95% CI, 1.165-3.086; P = 0.01) were also associated with RVO. Conclusions: An association between ESRD and subsequent RVO development was found after adjustment for possible confounding factors.
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1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Koh, Hyoung Jun(고형준) ORCID logo https://orcid.org/0000-0002-5932-8516
Nam, Ki Heon(남기헌) ORCID logo https://orcid.org/0000-0001-7312-7027
Lee, Kyung Sik(이경식)
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