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Changes in Clinical Characteristics of Patients with an Initial Diagnosis of Prostate Cancer in Korea: 10-Year Trends Reported by a Tertiary Center

Authors
 Ji Eun Heo  ;  Hyun Kyu Ahn  ;  Jinu Kim  ;  Byung Ha Chung  ;  Kwang Suk Lee 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.33(6) : e42, 2018 
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
ISSN
 1011-8934 
Issue Date
2018
MeSH
Aged ; Body Mass Index ; Disease-Free Survival ; Humans ; Male ; Middle Aged ; Multivariate Analysis ; Neoplasm Grading ; Neoplasm Staging ; Proportional Hazards Models ; Prostate-Specific Antigen/analysis ; Prostatic Neoplasms/diagnosis* ; Prostatic Neoplasms/mortality ; Prostatic Neoplasms/pathology ; Republic of Korea ; Survival Rate ; Tertiary Care Centers
Keywords
Biopsy ; Gleason Score ; Neoplasms, Prostate ; Prostate-Specific Antigen
Abstract
BACKGROUND:

The Korea Central Cancer Registry reported that incidence rates of prostate cancer have not increased continuously. We used recent trends in the incidence of prostate cancer to generate a preliminary report of the Korean population with prostate cancer.

METHODS:

Patients initially diagnosed with prostate cancer by prostate biopsy from 2006 to 2015 at our tertiary center were selected. All patients were categorized according to age (< 65, 65-75, > 75 years), time period (2006-2010 vs. 2011-2015), and risk classification. Patients with insufficient data were excluded from the analysis.

RESULTS:

Of 675 patients (median prostate-specific antigen [PSA], 9.09 ng/mL), those with a Gleason score (GS) of 6 (32.3%) comprised the largest proportion in our cohort. The proportion with a GS of 8 increased for those aged 65-75 years, despite the lack of increase in PSA. Treatment patterns changed for those with very low to low risk cancer. The overall survival (OS) rate and the cancer-specific survival (CSS) rate for all patients at 5 years were 87% and 90%, respectively. Patients with a low body mass index (BMI; ≤ 23 kg/m²) had worse median OS and CSS rates.

CONCLUSION:

Significant differences in risk classifications and initial treatments were found between 2006-2010 and 2011-2015. Although PSA did not change, the GS did change. Lower BMI (≤ 23 kg/m²) had worse effects on OS and CSS rates for Korean prostate cancer patients.
Files in This Item:
T201804144.pdf Download
DOI
10.3346/jkms.2018.33.e42
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Kwang Suk(이광석) ORCID logo https://orcid.org/0000-0002-7961-8393
Chung, Byung Ha(정병하) ORCID logo https://orcid.org/0000-0001-9817-3660
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165536
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