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Changes in Clinical Characteristics of Patients with an Initial Diagnosis of Prostate Cancer in Korea: 10-Year Trends Reported by a Tertiary Center

 Ji Eun Heo  ;  Hyun Kyu Ahn  ;  Jinu Kim  ;  Byung Ha Chung  ;  Kwang Suk Lee 
 Journal of Korean Medical Science, Vol.33(6) : e42, 2018 
Journal Title
 Journal of Korean Medical Science 
Issue Date
Aged ; Body Mass Index ; Disease-Free Survival ; Humans ; Male ; Middle Aged ; Multivariate Analysis ; Neoplasm Grading ; Neoplasm Staging ; Proportional Hazards Models ; Prostate-Specific Antigen/analysis ; Prostatic Neoplasms/diagnosis* ; Prostatic Neoplasms/mortality ; Prostatic Neoplasms/pathology ; Republic of Korea ; Survival Rate ; Tertiary Care Centers
Biopsy ; Gleason Score ; Neoplasms, Prostate ; Prostate-Specific Antigen
BACKGROUND: The Korea Central Cancer Registry reported that incidence rates of prostate cancer have not increased continuously. We used recent trends in the incidence of prostate cancer to generate a preliminary report of the Korean population with prostate cancer. METHODS: Patients initially diagnosed with prostate cancer by prostate biopsy from 2006 to 2015 at our tertiary center were selected. All patients were categorized according to age (< 65, 65-75, > 75 years), time period (2006-2010 vs. 2011-2015), and risk classification. Patients with insufficient data were excluded from the analysis. RESULTS: Of 675 patients (median prostate-specific antigen [PSA], 9.09 ng/mL), those with a Gleason score (GS) of 6 (32.3%) comprised the largest proportion in our cohort. The proportion with a GS of 8 increased for those aged 65-75 years, despite the lack of increase in PSA. Treatment patterns changed for those with very low to low risk cancer. The overall survival (OS) rate and the cancer-specific survival (CSS) rate for all patients at 5 years were 87% and 90%, respectively. Patients with a low body mass index (BMI; ≤ 23 kg/m²) had worse median OS and CSS rates. CONCLUSION: Significant differences in risk classifications and initial treatments were found between 2006-2010 and 2011-2015. Although PSA did not change, the GS did change. Lower BMI (≤ 23 kg/m²) had worse effects on OS and CSS rates for Korean prostate cancer patients.
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1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
이광석(Lee, Kwang Suk) ORCID logo https://orcid.org/0000-0002-7961-8393
정병하(Chung, Byung Ha) ORCID logo https://orcid.org/0000-0001-9817-3660
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