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Pseudoglandular Formation in Hepatocellular Carcinoma Determines Apparent Diffusion Coefficient in Diffusion-Weighted MRI

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dc.contributor.author김주희-
dc.contributor.author박인경-
dc.contributor.author유정식-
dc.contributor.author정재준-
dc.contributor.author조은석-
dc.date.accessioned2018-11-16T16:57:26Z-
dc.date.available2018-11-16T16:57:26Z-
dc.date.issued2018-
dc.identifier.issn2384-1095-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/165510-
dc.description.abstractPurpose: To determine the impact of pseudoglandular formation on apparent diffusion coefficient (ADC) values of hepatocellular carcinoma (HCC) in diffusionweighted imaging (DWI), and to validate the results using histopathological grades. Materials and Methods: We assessed 182 HCCs surgically resected from 169 consecutive patients. Each type of tumor pseudoglandular formation was categorized into “non-,” “mixed-,” or “pure-,” based on official histopathology reports. The ADC for each tumor was independently measured, using the largest region of interest on the ADC map. Data were assessed using the analysis of variance test, with Bonferroni correction for post hoc analysis to stratify the relationship of ADCs with pseudoglandular formation, followed by subgroup analysis according to the histopathological tumor grades. Results: The mean ADC was significantly higher in pure pseudoglandular lesions (n = 5, 1.29 ± 0.08 × 10-3 mm2/s) than in non- seudoglandular lesions (n = 132, 1.08 ± 0.17 × 10-3 mm2/s; P = 0.003) or mixed-pseudoglandular lesions (n = 45, 1.16 ± 0.24 × 10-3 mm2/s; P = 0.034). The ADC values and pseudoglandular formation were significantly correlated in moderately differentiated HCCs (n = 103; r = 0.307, P = 0.007), while well- (n = 19) and poorly-differentiated HCCs (n = 60) did not show significant correlation (r = 0.105 and 0.068, respectively; P = 0.600 and 0.685, respectively). Conclusion: The degree of pseudoglandular formation could be one of the determinants of ADC in DWI of HCCs-especially moderately differentiated HCCs-while its influence does not appear to be significant in well- or poorly differentiated HCCs.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherKorean Society of Magnetic Resonance in Medicine-
dc.relation.isPartOfInvestigative Magnetic Resonance Imaging-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titlePseudoglandular Formation in Hepatocellular Carcinoma Determines Apparent Diffusion Coefficient in Diffusion-Weighted MRI-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학교실)-
dc.contributor.googleauthorIn Kyung Park-
dc.contributor.googleauthorJeong-Sik Yu-
dc.contributor.googleauthorEun-Suk Cho-
dc.contributor.googleauthorJoo Hee Kim-
dc.contributor.googleauthorJae-Joon Chung-
dc.identifier.doi10.13104/imri.2018.22.2.79-
dc.contributor.localIdA00951-
dc.contributor.localIdA00951-
dc.contributor.localIdA05625-
dc.contributor.localIdA02500-
dc.contributor.localIdA03712-
dc.contributor.localIdA03881-
dc.relation.journalcodeJ01186-
dc.identifier.eissn2384-1109-
dc.subject.keywordDiffusion magnetic resonance imaging-
dc.subject.keywordCarcinoma, hepatocellular-
dc.subject.keywordLiver diseases-
dc.subject.keywordLiver neoplasms-
dc.contributor.alternativeNameKim, Joo Hee-
dc.contributor.alternativeNamePark,In Kyung-
dc.contributor.alternativeNameYu, Jeong Sik-
dc.contributor.alternativeNameChung, Jae Joon-
dc.contributor.alternativeNameCho, Eun Suk-
dc.contributor.affiliatedAuthor김주희-
dc.contributor.affiliatedAuthor박인경-
dc.contributor.affiliatedAuthor유정식-
dc.contributor.affiliatedAuthor정재준-
dc.contributor.affiliatedAuthor조은석-
dc.citation.volume22-
dc.citation.number2-
dc.citation.startPage79-
dc.citation.endPage85-
dc.identifier.bibliographicCitationInvestigative Magnetic Resonance Imaging, Vol.22(2) : 79-85, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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