51 81

Cited 3 times in

A hierarchical prognostic model for risk stratification in patients with early breast cancer according to 18 F-fludeoxyglucose uptake and clinicopathological parameters

DC FieldValueLanguage
dc.contributor.author김동우-
dc.contributor.author김민정-
dc.contributor.author김현정-
dc.contributor.author박형석-
dc.contributor.author윤미진-
dc.contributor.author조영업-
dc.contributor.author차종태-
dc.date.accessioned2018-11-16T16:53:46Z-
dc.date.available2018-11-16T16:53:46Z-
dc.date.issued2018-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/165444-
dc.description.abstractThis study was to investigate a hierarchical prognostic model using clinicopathological factors and 18 F-fludeoxyglucose (FDG) uptake on positron emission tomography/computed tomography (PET/CT) for recurrence-free survival (RFS) in patients with early breast cancer who underwent surgery without neoadjuvant chemotherapy. A total of 524 patients with early breast cancer were included. The Cox proportional hazards model was used with clinicopathological variables and maximum standardized uptake value (SUVmax) on PET/CT. After classification and regression tree (CART) modeling, RFS curves were estimated using the Kaplan-Meier method and differences in each risk layer were assessed using the log-rank test. During a median follow-up of 46.2 months, 31 (5.9%) patients experienced recurrence. The CART model identified four risk layers: group 1 (SUVmax ≤6.75 and tumor size ≤2.0 cm); group 2 (SUVmax ≤6.75 and Luminal A [LumA] or TN tumor >2.0 cm); group 3 (SUVmax ≤6.75 and Luminal B [LumB] or human epidermal growth factor receptor 2 [HER2]-enriched] tumor >2.0 cm); group 4 (SUVmax >6.75). Five-year RFS was as follows: 95.9% (group 1), 98% (group 2), 82.8% (group 3), and 85.4% (group 4). Group 3 or group 4 showed worse prognosis than group 1 or group 2 (group 1 vs. group 3: P = 0.040; group 1 vs. group 4: P < 0.001; group 2 vs. group 3: P = 0.016; group 2 vs. group 4: P < 0.001). High SUVmax (>6.75) in primary breast cancer was an independent factor for poor RFS. In patients with low SUVmax, LumB or HER2-enriched tumor >2 cm was also prognostic for poor RFS, similar to high SUVmax.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherJohn Wiley & Sons Ltd.-
dc.relation.isPartOfCancer Medicine-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleA hierarchical prognostic model for risk stratification in patients with early breast cancer according to 18 F-fludeoxyglucose uptake and clinicopathological parameters-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Nuclear Medicine (핵의학교실)-
dc.contributor.googleauthorJongtae Cha-
dc.contributor.googleauthorHyung Seok Park-
dc.contributor.googleauthorDongwoo Kim-
dc.contributor.googleauthorHyun Jeong Kim-
dc.contributor.googleauthorMin Jung Kim-
dc.contributor.googleauthorYoung Up Cho-
dc.contributor.googleauthorMijin Yun-
dc.identifier.doi10.1002/cam4.1394-
dc.contributor.localIdA05304-
dc.contributor.localIdA05304-
dc.contributor.localIdA00473-
dc.contributor.localIdA01129-
dc.contributor.localIdA01753-
dc.contributor.localIdA02550-
dc.contributor.localIdA05420-
dc.contributor.localIdA04801-
dc.relation.journalcodeJ00449-
dc.identifier.eissn2045-7634-
dc.identifier.pmid29479851-
dc.subject.keyword18F-FDG PET/CT-
dc.subject.keywordclassification and regression tree modeling-
dc.subject.keywordearly breast cancer-
dc.subject.keywordrecurrence-free survival-
dc.subject.keywordrisk model-
dc.contributor.alternativeNameKim, Dongwoo-
dc.contributor.alternativeNameKim, Min Jung-
dc.contributor.alternativeNameKim, Hyun Jeong-
dc.contributor.alternativeNamePark, Hyung Seok-
dc.contributor.alternativeNameYun, Mi Jin-
dc.contributor.alternativeNameCho, Young Up-
dc.contributor.alternativeNameCha, Jongtae-
dc.contributor.affiliatedAuthor김동우-
dc.contributor.affiliatedAuthor김민정-
dc.contributor.affiliatedAuthor김현정-
dc.contributor.affiliatedAuthor박형석-
dc.contributor.affiliatedAuthor윤미진-
dc.contributor.affiliatedAuthor조영업-
dc.contributor.affiliatedAuthor차종태-
dc.citation.volume7-
dc.citation.number4-
dc.citation.startPage1127-
dc.citation.endPage1134-
dc.identifier.bibliographicCitationCancer Medicine, Vol.7(4) : 1127-1134, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.