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Comparison of tumor-infiltrating lymphocytes of breast cancer in core needle biopsies and resected specimens: a retrospective analysis.

DC FieldValueLanguage
dc.contributor.author배숭준-
dc.contributor.author서자영-
dc.contributor.author손은주-
dc.contributor.author안성귀-
dc.contributor.author윤창익-
dc.contributor.author정우희-
dc.contributor.author정준-
dc.contributor.author차윤진-
dc.date.accessioned2018-11-16T16:53:05Z-
dc.date.available2018-11-16T16:53:05Z-
dc.date.issued2018-
dc.identifier.issn0167-6806-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/165433-
dc.description.abstractPURPOSE: Neoadjuvant chemotherapy (NAC) is being increasingly used to treat locally advanced breast cancer and to conserve the breast. In triple-negative breast cancer and HER2-positive breast cancer, a high density of tumor-infiltrating lymphocytes (TILs) is an important predictor of NAC response. Thus far, it remains unclear whether the TIL scores in core needle biopsies (CNBs) are closely representative of those in the whole tumor section in resected specimens. This study aimed to evaluate the concordance between the TIL scores of CNBs and resected specimens of breast cancer. METHODS: A total of 220 matched pairs of CNBs and resected specimens of breast cancer were included. Stromal TILs were scored on slides stained with hematoxylin and eosin. Clinicopathologic parameters and the agreement of the TIL scores between CNBs and resected specimens were statistically analyzed. RESULTS: The average TIL score was approximately 4.4% higher for the resected specimens than for the CNBs. When the tumors were divided into two groups according to a 60% TIL score cut-off (low and intermediate TIL vs. high TIL), 8.2% showed discordance between the CNB and resected specimen. The overall intraclass correlation coefficient (ICC) value of the TIL score was 0.895 (95% confidence interval, 0.864-0.920, P < 0.001), and all molecular subtypes showed ICC values over 0.8 (P < 0.001). The ICC values were > 0.9 when ≥ 5 cores were included in the CNBs. Tumors with discordant TILs were characterized by histologic grade III, ER negativity, high proliferative index, and HER2 and triple-negative subtypes. A high proliferative index was an independent risk factor for TIL discordance. CONCLUSIONS: The TIL score in CNB specimens is a reliable value that reflects the TIL status of the entire tumor in resected specimens of breast cancer. More than five CNB cores may accurately predict the TIL score of the entire tumor.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherKluwer Academic-
dc.relation.isPartOfBREAST CANCER RESEARCH AND TREATMENT-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleComparison of tumor-infiltrating lymphocytes of breast cancer in core needle biopsies and resected specimens: a retrospective analysis.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorYoon Jin Cha-
dc.contributor.googleauthorSung Gwe Ahn-
dc.contributor.googleauthorSoong June Bae-
dc.contributor.googleauthorChang Ik Yoon-
dc.contributor.googleauthorJayeong Seo-
dc.contributor.googleauthorWoo Hee Jung-
dc.contributor.googleauthorEun Ju Son-
dc.contributor.googleauthorJoon Jeong-
dc.identifier.doi10.1007/s10549-018-4842-7-
dc.contributor.localIdA05345-
dc.contributor.localIdA05349-
dc.contributor.localIdA01988-
dc.contributor.localIdA02231-
dc.contributor.localIdA05369-
dc.contributor.localIdA03671-
dc.contributor.localIdA03727-
dc.contributor.localIdA04001-
dc.relation.journalcodeJ00403-
dc.identifier.eissn1573-7217-
dc.identifier.pmid29869774-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs10549-018-4842-7-
dc.subject.keywordBreast neoplasms-
dc.subject.keywordCore needle biopsy-
dc.subject.keywordLymphocytes, Tumor-infiltrating-
dc.subject.keywordMastectomy, Modified radical-
dc.subject.keywordMastectomy, Segmental-
dc.subject.keywordNeoadjuvant therapy-
dc.contributor.alternativeNameBae, Soong June-
dc.contributor.alternativeNameSeo, Jayeong-
dc.contributor.alternativeNameSon, Eun Ju-
dc.contributor.alternativeNameAhn, Sung Gwe-
dc.contributor.alternativeNameYoon, Changik-
dc.contributor.alternativeNameJung, Woo Hee-
dc.contributor.alternativeNameJeong, Joon-
dc.contributor.alternativeNameCha, Yoon Jin-
dc.contributor.affiliatedAuthor배숭준-
dc.contributor.affiliatedAuthor서자영-
dc.contributor.affiliatedAuthor손은주-
dc.contributor.affiliatedAuthor안성귀-
dc.contributor.affiliatedAuthor윤창익-
dc.contributor.affiliatedAuthor정우희-
dc.contributor.affiliatedAuthor정준-
dc.contributor.affiliatedAuthor차윤진-
dc.citation.volume171-
dc.citation.number2-
dc.citation.startPage295-
dc.citation.endPage302-
dc.identifier.bibliographicCitationBREAST CANCER RESEARCH AND TREATMENT, Vol.171(2) : 295-302, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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