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The risk factors of miscarriage and obstetrical outcomes of intrauterine normal pregnancy following heterotopic pregnancy management.

 Eun Duc Na  ;  Inkyung Jung  ;  Dong Hee Choi  ;  Hwang Kwon  ;  Seok Jae Heo  ;  Hyeon Chul Kim  ;  Suk Ho Kang  ;  HeeYoung Cho 
 MEDICINE, Vol.97(37) : e12233, 2018 
Journal Title
Issue Date
Abortion, Spontaneous/epidemiology* ; Early Diagnosis ; Female ; Gestational Age ; Humans ; Pregnancy ; Pregnancy Outcome/epidemiology* ; Pregnancy, Heterotopic/diagnosis ; Pregnancy, Heterotopic/epidemiology* ; Pregnancy, Heterotopic/therapy* ; Retrospective Studies ; Risk Factors ; Ultrasonography, Prenatal
fetal heart beat ; gestational age ; heterotopic pregnancy ; miscarriage ; outcome
To investigate the clinical characteristics and risk factors for miscarriage of intrauterine normal pregnancy of patients with a heterotopic pregnancy (HP) after treatment.This was a retrospective study of medical records from CHA Bundang Medical Center. Sixty-four patients who were diagnosed with a HP between February 2006 and July 2017 were included in this study. All analyses were performed using SAS software, version 9.4 (SAS Institute, Inc., Cary, NC). P values < .05 were considered statistically significant.Forty-eight patients had tubal ectopic pregnancies (EP), 10 patients had cornual EPs, 1 patient had a cesarean section scar EP, 4 patients had an ovarian EP, and 1 patient had bilateral tubal EP. Among the 64 patients, 14.1% (9/64) miscarried before 10 weeks of gestation after management. Mean gestational age (GA) at treatment was 5.97 ± 0.50 weeks and 6.80 ± 1.04 weeks for miscarriage and nonmiscarriage group, respectively (P = .008). Significant differences were observed between 2 groups in terms of ultrasonographic features at the time HP was diagnosed (P = .040) Logistic regression models indicated that gestational age at treatment showed significant differences between 2 groups (OR: 0.003, 95% CI: 0.001-0.604).Immediate management after diagnosis could expect favorable prognosis of HP. GA at treatment was the only independent risk factor for miscarriage in patients with HP regardless of treatment methods.
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1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
Yonsei Authors
Jung, Inkyung(정인경) ORCID logo https://orcid.org/0000-0003-3780-3213
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