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Prognostic factors predicting survival in incurable stage IV colorectal cancer patients who underwent palliative primary tumor resection. Retrospective cohort study.

Authors
 Min Sung Kim  ;  Eun Jung Park  ;  Jeonghyun Kang  ;  Byung Soh Min  ;  Kang Young Lee  ;  Nam Kyu Kim  ;  Seung Hyuk Baik 
Citation
 INTERNATIONAL JOURNAL OF SURGERY, Vol.49 : 10-15, 2018 
Journal Title
 INTERNATIONAL JOURNAL OF SURGERY 
ISSN
 1743-9191 
Issue Date
2018
MeSH
Adult ; Aged ; Aged, 80 and over ; Colectomy/methods ; Colectomy/mortality* ; Colorectal Neoplasms/mortality* ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/surgery ; Female ; Humans ; Male ; Middle Aged ; Multivariate Analysis ; Neoplasm Staging ; Palliative Care/methods* ; Prognosis ; Retrospective Studies ; Survival Analysis ; Treatment Outcome
Keywords
Neoplasm metastasis ; Surgical treatment ; Survival ; colorectal adenocarcinomas
Abstract
BACKGROUND: The aim of this study is to estimate prognostic factors predicting survival in patients with incurable stage IV colorectal cancer (CRC), who underwent palliative primary tumor resection (PTR) with chemotherapy. MATERIALS AND METHODS: We retrospectively performed an analysis using clinicopathological parameters of 103 patients with incurable stage IV CRC, who underwent palliative PTR with chemotherapy between 2006 and 2010. Prognostic factors associated with overall survival (OS) were evaluated by univariate and multivariate analyses. RESULTS: The median follow-up time was 17.5 months (range 2.4-60.5) for the total cohort (n = 103). There were five independent factors related to OS in univariate analysis (body mass index, tumor differentiation, pT, pN stage and local clearance of the primary tumor). A multivariate analysis revealed that pT, pN and local clearance of the primary tumor were prognostic factors related to OS. Median survival months (95% CI) were pT1, 2, 3: 21.5 (16.23-26.77) months vs. pT4: 13.73 (9.94-17.53) months, pN-: 29.7 (22.55-35.99) months vs. pN+: 17.1 (15.0-19.41) months and R0: 18.57 (16.65-20.48) months vs. R1, 2: 12.43 (9.95-14.91) months. CONCLUSION: Locally advanced primary tumor (high pT stage, positive regional lymph node, and local residual primary tumor) was associated with poorer OS in incurable stage IV CRC patients, who underwent palliative PTR with chemotherapy. The PTR appears to result in better OS in patients with a primary tumor that is not locally advanced.
Full Text
https://www.sciencedirect.com/science/article/pii/S1743919117314577
DOI
10.1016/j.ijsu.2017.11.038
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Jeonghyun(강정현) ORCID logo https://orcid.org/0000-0001-7311-6053
Kim, Nam Kyu(김남규) ORCID logo https://orcid.org/0000-0003-0639-5632
Min, Byung Soh(민병소) ORCID logo https://orcid.org/0000-0003-0180-8565
Park, Eun Jung(박은정) ORCID logo https://orcid.org/0000-0002-4559-2690
Baik, Seung Hyuk(백승혁) ORCID logo https://orcid.org/0000-0003-4183-2332
Lee, Kang Young(이강영)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165363
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