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Prognostic factors predicting survival in incurable stage IV colorectal cancer patients who underwent palliative primary tumor resection. Retrospective cohort study.

DC Field Value Language
dc.contributor.author강정현-
dc.contributor.author김남규-
dc.contributor.author민병소-
dc.contributor.author박은정-
dc.contributor.author백승혁-
dc.contributor.author이강영-
dc.date.accessioned2018-11-16T16:49:23Z-
dc.date.available2018-11-16T16:49:23Z-
dc.date.issued2018-
dc.identifier.issn1743-9191-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/165363-
dc.description.abstractBACKGROUND: The aim of this study is to estimate prognostic factors predicting survival in patients with incurable stage IV colorectal cancer (CRC), who underwent palliative primary tumor resection (PTR) with chemotherapy. MATERIALS AND METHODS: We retrospectively performed an analysis using clinicopathological parameters of 103 patients with incurable stage IV CRC, who underwent palliative PTR with chemotherapy between 2006 and 2010. Prognostic factors associated with overall survival (OS) were evaluated by univariate and multivariate analyses. RESULTS: The median follow-up time was 17.5 months (range 2.4-60.5) for the total cohort (n = 103). There were five independent factors related to OS in univariate analysis (body mass index, tumor differentiation, pT, pN stage and local clearance of the primary tumor). A multivariate analysis revealed that pT, pN and local clearance of the primary tumor were prognostic factors related to OS. Median survival months (95% CI) were pT1, 2, 3: 21.5 (16.23-26.77) months vs. pT4: 13.73 (9.94-17.53) months, pN-: 29.7 (22.55-35.99) months vs. pN+: 17.1 (15.0-19.41) months and R0: 18.57 (16.65-20.48) months vs. R1, 2: 12.43 (9.95-14.91) months. CONCLUSION: Locally advanced primary tumor (high pT stage, positive regional lymph node, and local residual primary tumor) was associated with poorer OS in incurable stage IV CRC patients, who underwent palliative PTR with chemotherapy. The PTR appears to result in better OS in patients with a primary tumor that is not locally advanced.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF SURGERY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHColectomy/methods-
dc.subject.MESHColectomy/mortality*-
dc.subject.MESHColorectal Neoplasms/mortality*-
dc.subject.MESHColorectal Neoplasms/pathology-
dc.subject.MESHColorectal Neoplasms/surgery-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPalliative Care/methods*-
dc.subject.MESHPrognosis-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSurvival Analysis-
dc.subject.MESHTreatment Outcome-
dc.titlePrognostic factors predicting survival in incurable stage IV colorectal cancer patients who underwent palliative primary tumor resection. Retrospective cohort study.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorMin Sung Kim-
dc.contributor.googleauthorEun Jung Park-
dc.contributor.googleauthorJeonghyun Kang-
dc.contributor.googleauthorByung Soh Min-
dc.contributor.googleauthorKang Young Lee-
dc.contributor.googleauthorNam Kyu Kim-
dc.contributor.googleauthorSeung Hyuk Baik-
dc.identifier.doi10.1016/j.ijsu.2017.11.038-
dc.contributor.localIdA00080-
dc.contributor.localIdA00353-
dc.contributor.localIdA01402-
dc.contributor.localIdA04572-
dc.contributor.localIdA01827-
dc.contributor.localIdA02640-
dc.relation.journalcodeJ01162-
dc.identifier.eissn1743-9159-
dc.identifier.pmid29198632-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S1743919117314577-
dc.subject.keywordNeoplasm metastasis-
dc.subject.keywordSurgical treatment-
dc.subject.keywordSurvival-
dc.subject.keywordcolorectal adenocarcinomas-
dc.contributor.alternativeNameKang, Jeonghyun-
dc.contributor.alternativeNameKim, Nam Kyu-
dc.contributor.alternativeNameMin, Byung Soh-
dc.contributor.alternativeNamePark, Eun Jung-
dc.contributor.alternativeNameBaik, Seung Hyuk-
dc.contributor.alternativeNameLee, Kang Young-
dc.contributor.affiliatedAuthor강정현-
dc.contributor.affiliatedAuthor김남규-
dc.contributor.affiliatedAuthor민병소-
dc.contributor.affiliatedAuthor박은정-
dc.contributor.affiliatedAuthor백승혁-
dc.contributor.affiliatedAuthor이강영-
dc.citation.volume49-
dc.citation.startPage10-
dc.citation.endPage15-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF SURGERY, Vol.49 : 10-15, 2018-
dc.identifier.rimsid58775-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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