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Allergen-specific immunotherapy induces regulatory T cells in an atopic dermatitis mouse model.

Authors
 J. U. Shin  ;  S. H. Kim  ;  J. Y. Noh  ;  J. H. Kim  ;  H. R. Kim  ;  K. Y. Jeong  ;  K. H. Park  ;  J. Lee  ;  H. Chu  ;  J.‐H. Lee  ;  T.‐S. Yong  ;  J.‐W. Park  ;  K. H. Lee 
Citation
 Allergy, Vol.73(9) : 1801-1811, 2018 
Journal Title
 Allergy 
ISSN
 0105-4538 
Issue Date
2018
Keywords
Dermatophagoides farinae extract ; allergen-specific immunotherapy ; atopic dermatitis ; regulatory T (Treg) cells
Abstract
BACKGROUND: Several studies have demonstrated that allergen-specific immunotherapy (SIT) can be an effective treatment for atopic dermatitis (AD). However, there is no relevant mouse model to investigate the mechanism and validate the novel modality of SIT in AD. METHODS: NC/Nga mice with induced AD-like skin lesions received a subcutaneous injection of SIT (an extract of the house dust mite Dermatophagoides farinae [DfE]) or placebo for 5 weeks). Clinical and histological improvements of AD-like skin lesions were examined. The responses of local and systemic regulatory T (Treg) cells, natural killer (NK) cells, B cells, serum immunoglobulin, and T-cell cytokine response to DfE were evaluated to determine the underlying mechanism of the observed results. RESULTS: Specific immunotherapy significantly improved AD-like skin lesions. Histologically, SIT decreased epidermal thickness and reduced inflammatory cell infiltration, especially that of eosinophils. Concomitantly, SIT suppressed Th2 responses and induced local infiltration of Treg cells into the skin. Also, SIT induced the immunoglobulin G4 and attenuated allergen-specific immunoglobulin E. Furthermore, SIT induced local and systemic IL-10-producing Treg cells and regulatory NK cells. CONCLUSION: We established a SIT model on AD mice and showed that our model correlates well with previous reports about SIT-treated patients. Also, we revealed NK cells as another possible resource of IL-10 in SIT. Based on our results, we suggest our SIT model as a useful tool to investigate mechanism of action of SIT and to validate the efficacy of new SIT modalities for the treatment of AD.
Full Text
https://onlinelibrary.wiley.com/doi/full/10.1111/all.13465
DOI
10.1111/all.13465
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Environmental Medical Biology (환경의생물학교실)
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Institute of Allergy (알레르기연구소)
Yonsei Authors
노지연(Noh, Ji Yeon)
박경희(Park, Kyung Hee) ORCID logo https://orcid.org/0000-0003-3605-5364
박중원(Park, Jung Won)
신정우(Shin, Jung U) ORCID logo https://orcid.org/0000-0001-5259-6879
용태순(Yong, Tai Soon)
이광훈(Lee, Kwang Hoon)
이재현(Lee, Jae Hyun) ORCID logo https://orcid.org/0000-0002-0760-0071
이주희(Lee, Ju Hee) ORCID logo https://orcid.org/0000-0002-1739-5956
정경용(Jeong, Kyoung Yong) ORCID logo https://orcid.org/0000-0001-9887-1426
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165286
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