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Potential of serum soluble CD93 as a biomarker for asthma in an ovalbumin-induced asthma murine model

Authors
 Hye Jung Park  ;  Eun-Yi Oh  ;  Yoon Hee Park  ;  Misuk Yang  ;  Kyung Hee Park  ;  Jung-Won Park  ;  Jae-Hyun Lee 
Citation
 Biomarkers, Vol.23(5) : 446-452, 2018 
Journal Title
 Biomarkers 
ISSN
 1354-750X 
Issue Date
2018
MeSH
Animals ; Asthma/blood ; Asthma/chemically induced ; Asthma/diagnosis* ; Asthma/pathology ; Biomarkers/blood ; Inflammation/blood ; Membrane Glycoproteins/blood* ; Mice ; Ovalbumin/adverse effects ; Receptors, Complement/blood*
Keywords
Airway ; CD93 ; asthma ; biomarker ; inflammation ; ovalbumin
Abstract
BACKGROUND: CD93 is a membrane-associated glycoprotein, which can be released in a soluble form (sCD93) into the serum. CD93 has received renewed attention as a candidate biomarker of inflammation in various inflammatory and immune-mediated diseases, including asthma. OBJECTIVE: We aimed to evaluate the effects of airway inflammation on CD93 levels in murine models. METHODS: We established an ovalbumin (OVA)-induced acute asthma murine model (OVA model) and a lipopolysaccharide (LPS)-induced airway inflammation murine model (LPS model). Dexamethasone was administered by gavage to attenuate the airway inflammation. RESULTS: The OVA model demonstrated typical allergic asthma features with increased airway hyper-responsiveness, inflammatory cell infiltration, increased Th2 cytokine levels, compared to the control group. CD93 levels were decreased in lung homogenates and, respiratory epithelial cells, whereas serum sCD93 levels were increased in the OVA model, as compared to the control group. Dexamethasone reversed these effects of OVA. In contrast, in the LPS model, CD93 levels were not affected in neither respiratory epithelial cells nor serum. CONCLUSIONS: Our findings demonstrate the potential of using sCD93 as a biomarker for allergic asthma.
Full Text
https://www.tandfonline.com/doi/full/10.1080/1354750X.2018.1443510
DOI
10.1080/1354750X.2018.1443510
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
박경희(Park, Kyung Hee) ORCID logo https://orcid.org/0000-0003-3605-5364
박중원(Park, Jung Won) ORCID logo https://orcid.org/0000-0003-0249-8749
박혜정(Park, Hye Jung) ORCID logo https://orcid.org/0000-0002-1862-1003
이재현(Lee, Jae Hyun) ORCID logo https://orcid.org/0000-0002-0760-0071
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165248
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