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Phospholipase Cgamma activation drives increased production of autotaxin in endothelial cells and lysophosphatidic acid-dependent regression

Authors
 Eunok Im  ;  Ruta Motiejunaite  ;  Jorge Aranda  ;  Eun Young Park  ;  Lorenzo Federico  ;  Tae-im Kim  ;  Timothy Clair  ;  Mary L. Stracke  ;  Susan Smyth  ;  Andrius Kazlauskas 
Citation
 MOLECULAR AND CELLULAR BIOLOGY, Vol.30(10) : 2401-2410, 2010 
Journal Title
 MOLECULAR AND CELLULAR BIOLOGY 
ISSN
 0270-7306 
Issue Date
2010
Abstract
We previously reported that vascular endothelial growth factor (VEGF)-dependent activation of phospholipase Cgamma1 (PLCgamma) regulated tube stability by competing with phosphoinositide 3-kinase (PI3K) for their common substrate. Here we describe an additional mechanism by which PLCgamma promoted regression of tubes and blood vessels. Namely, it increased the level of autotaxin (ATX), which is a secreted form of lysophospholipase D that produces lysophosphatidic acid (LPA). LPA promoted motility of endothelial cells, leading to disorganization/regression of tubes in vitro. Furthermore, mice that under- or overexpressed members of this intrinsic destabilization pathway showed either delayed or accelerated, respectively, regression of blood vessels. We conclude that endothelial cells can be instructed to engage a PLCgamma-dependent intrinsic destabilization pathway that results in the production of soluble regression factors such as ATX and LPA. These findings are likely to potentiate ongoing efforts to prevent, manage, and eradicate numerous angiogenesis-based diseases such as proliferative diabetic retinopathy and solid tumors.
Files in This Item:
T999900118.pdf Download
DOI
10.1128/MCB.01275-09
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Tae Im(김태임) ORCID logo https://orcid.org/0000-0001-6414-3842
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165023
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