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Use of Sedative-Hypnotics and Mortality: A Population-Based Retrospective Cohort Study

Authors
 Jae-Won Choi  ;  Joonki Lee  ;  Sun Jae Jung  ;  Aesun Shin  ;  Yu Jin Lee 
Citation
 JOURNAL OF CLINICAL SLEEP MEDICINE, Vol.14(10) : 1669-1677, 2018 
Journal Title
 JOURNAL OF CLINICAL SLEEP MEDICINE 
ISSN
 1550-9389 
Issue Date
2018
Keywords
mortality ; sedative-hypnotics ; zolpidem
Abstract
STUDY OBJECTIVES: Researchers have previously reported a possible association between sedative-hypnotics and increased mortality. However, the relationship remains controversial. We investigated the association between sedative-hypnotics and mortality using a large population-based database from the Republic of Korea. METHODS: We used a National Health Insurance Service database. The study population was a 5% random sample of the database from the years 2002- 2015. Individuals who were age 40 years and older were included in the analysis. The sedative-hypnotic users were defined as individuals prescribed 30 or more defined daily doses of sedative-hypnotics per year since January 2004. Sedative-hypnotics were classified based on type and total amount. We estimated the risk of mortality (death from January 2004 to December 2015) using time-dependent Cox regression model adjusted for age, sex, Charlson Comorbidity Index, and psychiatric comorbidity. RESULTS: We identified 180,823 study participants who used sedative-hypnotics and 320,136 nonusers. In a multivariate model, study participants who used sedative-hypnotics had significantly higher mortality risk than nonusers (hazard ratio [HR] 1.14, 95% confidence interval [CI] 1.12-1.16). Specifically, study participants who used zolpidem had a higher mortality risk (HR 1.59, 95% CI 1.52-1.67) than nonusers. CONCLUSIONS: Based on the current study results, sedative-hypnotics were associated with an increased risk of mortality, especially in study participants who used zolpidem.
Full Text
http://jcsm.aasm.org/ViewAbstract.aspx?pid=31399
DOI
10.5664/jcsm.7370
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Jung, Sun Jae(정선재) ORCID logo https://orcid.org/0000-0002-5194-7339
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/164986
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