Cited 17 times in
Use of Sedative-Hypnotics and Mortality: A Population-Based Retrospective Cohort Study
DC Field | Value | Language |
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dc.contributor.author | 정선재 | - |
dc.date.accessioned | 2018-11-01T16:41:03Z | - |
dc.date.available | 2018-11-01T16:41:03Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1550-9389 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/164986 | - |
dc.description.abstract | STUDY OBJECTIVES: Researchers have previously reported a possible association between sedative-hypnotics and increased mortality. However, the relationship remains controversial. We investigated the association between sedative-hypnotics and mortality using a large population-based database from the Republic of Korea. METHODS: We used a National Health Insurance Service database. The study population was a 5% random sample of the database from the years 2002- 2015. Individuals who were age 40 years and older were included in the analysis. The sedative-hypnotic users were defined as individuals prescribed 30 or more defined daily doses of sedative-hypnotics per year since January 2004. Sedative-hypnotics were classified based on type and total amount. We estimated the risk of mortality (death from January 2004 to December 2015) using time-dependent Cox regression model adjusted for age, sex, Charlson Comorbidity Index, and psychiatric comorbidity. RESULTS: We identified 180,823 study participants who used sedative-hypnotics and 320,136 nonusers. In a multivariate model, study participants who used sedative-hypnotics had significantly higher mortality risk than nonusers (hazard ratio [HR] 1.14, 95% confidence interval [CI] 1.12-1.16). Specifically, study participants who used zolpidem had a higher mortality risk (HR 1.59, 95% CI 1.52-1.67) than nonusers. CONCLUSIONS: Based on the current study results, sedative-hypnotics were associated with an increased risk of mortality, especially in study participants who used zolpidem. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | American Academy of Sleep Medicine | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL SLEEP MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Use of Sedative-Hypnotics and Mortality: A Population-Based Retrospective Cohort Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Preventive Medicine and Public Health (예방의학교실) | - |
dc.contributor.googleauthor | Jae-Won Choi | - |
dc.contributor.googleauthor | Joonki Lee | - |
dc.contributor.googleauthor | Sun Jae Jung | - |
dc.contributor.googleauthor | Aesun Shin | - |
dc.contributor.googleauthor | Yu Jin Lee | - |
dc.identifier.doi | 10.5664/jcsm.7370 | - |
dc.contributor.localId | A05546 | - |
dc.relation.journalcode | J01341 | - |
dc.identifier.eissn | 1550-9397 | - |
dc.identifier.pmid | 30353805 | - |
dc.identifier.url | http://jcsm.aasm.org/ViewAbstract.aspx?pid=31399 | - |
dc.subject.keyword | mortality | - |
dc.subject.keyword | sedative-hypnotics | - |
dc.subject.keyword | zolpidem | - |
dc.contributor.alternativeName | Jung, Sun Jae | - |
dc.contributor.affiliatedAuthor | 정선재 | - |
dc.citation.volume | 14 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1669 | - |
dc.citation.endPage | 1677 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL SLEEP MEDICINE, Vol.14(10) : 1669-1677, 2018 | - |
dc.identifier.rimsid | 58305 | - |
dc.type.rims | ART | - |
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