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Microsphere-Based Nanoindentation for the Monitoring of Cellular Cortical Stiffness Regulated by MT1-MMP

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dc.contributor.author구민희-
dc.contributor.author김남희-
dc.contributor.author서진석-
dc.contributor.author양재문-
dc.contributor.author육종인-
dc.date.accessioned2018-11-01T16:40:58Z-
dc.date.available2018-11-01T16:40:58Z-
dc.date.issued2018-
dc.identifier.issn1613-6810-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/164985-
dc.description.abstractBiophysical properties are intimately connected to metastatic functions and aggressiveness in cancers. Especially, cellular stiffness is regarded as a biomarker for the understanding of metastatic potential and drug sensitivity. Here, protease-mediated changes of cortical stiffness are identified due to the deformation of cytoskeleton alignment at a cortex. For the past few decades, membrane type 1-matrix metalloproteinase (MT1-MMP) has been well known as a kernel protease enriched in podosomes during metastasis for extracellular matrix degradation. However, the biophysical significance of MT1-MMP expressing cancer cells is still unknown. Therefore, the nanomechanics of cancer cells is analyzed by a nanoindentation using a microsphere-attached cantilever of atomic force microscopy (AFM). In conclusion, the results suggest that MT1-MMP has contributed as a key regulator in cytoskeletal deformation related with cancer metastasis. Particularly, the AFM-based nanoindentation system for the monitoring of cortical nanomechanics will be crucial to understand molecular networks in cancers.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-VCH-
dc.relation.isPartOfSMALL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleMicrosphere-Based Nanoindentation for the Monitoring of Cellular Cortical Stiffness Regulated by MT1-MMP-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학교실)-
dc.contributor.googleauthorMinhee Ku-
dc.contributor.googleauthorHyun‐Joon Kim-
dc.contributor.googleauthorSu Yee Yau-
dc.contributor.googleauthorNara Yoon-
dc.contributor.googleauthorNam Hee Kim-
dc.contributor.googleauthorJong In Yook-
dc.contributor.googleauthorJin‐Suck Suh-
dc.contributor.googleauthorDae‐Eun Kim-
dc.contributor.googleauthorJaemoon Yang-
dc.identifier.doi10.1002/smll.201803000-
dc.contributor.localIdA00191-
dc.contributor.localIdA00360-
dc.contributor.localIdA01916-
dc.contributor.localIdA02315-
dc.contributor.localIdA02536-
dc.relation.journalcodeJ02664-
dc.identifier.eissn1613-6829-
dc.identifier.pmid30350552-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/abs/10.1002/smll.201803000-
dc.subject.keywordMT1‐MMP-
dc.subject.keywordatomic force microscopy-
dc.subject.keywordcancer mechanobiology-
dc.subject.keywordcortical stiffness-
dc.subject.keywordnanoindentation-
dc.contributor.alternativeNameKu, Min Hee-
dc.contributor.alternativeNameKim, Nam Hee-
dc.contributor.alternativeNameSuh, Jin Suck-
dc.contributor.alternativeNameYang, Jae Moon-
dc.contributor.alternativeNameYook, Jong In-
dc.contributor.affiliatedAuthor구민희-
dc.contributor.affiliatedAuthor김남희-
dc.contributor.affiliatedAuthor서진석-
dc.contributor.affiliatedAuthor양재문-
dc.contributor.affiliatedAuthor육종인-
dc.citation.volume14-
dc.citation.number41-
dc.citation.startPagee1803000-
dc.identifier.bibliographicCitationSMALL, Vol.14(41) : e1803000, 2018-
dc.identifier.rimsid58304-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers

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