Cited 6 times in
Microsphere-Based Nanoindentation for the Monitoring of Cellular Cortical Stiffness Regulated by MT1-MMP
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 구민희 | - |
dc.contributor.author | 김남희 | - |
dc.contributor.author | 서진석 | - |
dc.contributor.author | 양재문 | - |
dc.contributor.author | 육종인 | - |
dc.date.accessioned | 2018-11-01T16:40:58Z | - |
dc.date.available | 2018-11-01T16:40:58Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1613-6810 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/164985 | - |
dc.description.abstract | Biophysical properties are intimately connected to metastatic functions and aggressiveness in cancers. Especially, cellular stiffness is regarded as a biomarker for the understanding of metastatic potential and drug sensitivity. Here, protease-mediated changes of cortical stiffness are identified due to the deformation of cytoskeleton alignment at a cortex. For the past few decades, membrane type 1-matrix metalloproteinase (MT1-MMP) has been well known as a kernel protease enriched in podosomes during metastasis for extracellular matrix degradation. However, the biophysical significance of MT1-MMP expressing cancer cells is still unknown. Therefore, the nanomechanics of cancer cells is analyzed by a nanoindentation using a microsphere-attached cantilever of atomic force microscopy (AFM). In conclusion, the results suggest that MT1-MMP has contributed as a key regulator in cytoskeletal deformation related with cancer metastasis. Particularly, the AFM-based nanoindentation system for the monitoring of cortical nanomechanics will be crucial to understand molecular networks in cancers. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley-VCH | - |
dc.relation.isPartOf | SMALL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Microsphere-Based Nanoindentation for the Monitoring of Cellular Cortical Stiffness Regulated by MT1-MMP | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학교실) | - |
dc.contributor.googleauthor | Minhee Ku | - |
dc.contributor.googleauthor | Hyun‐Joon Kim | - |
dc.contributor.googleauthor | Su Yee Yau | - |
dc.contributor.googleauthor | Nara Yoon | - |
dc.contributor.googleauthor | Nam Hee Kim | - |
dc.contributor.googleauthor | Jong In Yook | - |
dc.contributor.googleauthor | Jin‐Suck Suh | - |
dc.contributor.googleauthor | Dae‐Eun Kim | - |
dc.contributor.googleauthor | Jaemoon Yang | - |
dc.identifier.doi | 10.1002/smll.201803000 | - |
dc.contributor.localId | A00191 | - |
dc.contributor.localId | A00360 | - |
dc.contributor.localId | A01916 | - |
dc.contributor.localId | A02315 | - |
dc.contributor.localId | A02536 | - |
dc.relation.journalcode | J02664 | - |
dc.identifier.eissn | 1613-6829 | - |
dc.identifier.pmid | 30350552 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.201803000 | - |
dc.subject.keyword | MT1‐MMP | - |
dc.subject.keyword | atomic force microscopy | - |
dc.subject.keyword | cancer mechanobiology | - |
dc.subject.keyword | cortical stiffness | - |
dc.subject.keyword | nanoindentation | - |
dc.contributor.alternativeName | Ku, Min Hee | - |
dc.contributor.alternativeName | Kim, Nam Hee | - |
dc.contributor.alternativeName | Suh, Jin Suck | - |
dc.contributor.alternativeName | Yang, Jae Moon | - |
dc.contributor.alternativeName | Yook, Jong In | - |
dc.contributor.affiliatedAuthor | 구민희 | - |
dc.contributor.affiliatedAuthor | 김남희 | - |
dc.contributor.affiliatedAuthor | 서진석 | - |
dc.contributor.affiliatedAuthor | 양재문 | - |
dc.contributor.affiliatedAuthor | 육종인 | - |
dc.citation.volume | 14 | - |
dc.citation.number | 41 | - |
dc.citation.startPage | e1803000 | - |
dc.identifier.bibliographicCitation | SMALL, Vol.14(41) : e1803000, 2018 | - |
dc.identifier.rimsid | 58304 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.