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3D-printed polycaprolactone scaffold mixed with β-tricalcium phosphate as a bone regenerative material in rabbit calvarial defects

Authors
 Hyung-Chul Pae  ;  Joo-Hyun Kang  ;  Jae-Kook Cha  ;  Jung-Seok Lee  ;  Jeong-Won Paik  ;  Ui-Won Jung  ;  Byung-Hoon Kim  ;  Seong-Ho Choi 
Citation
 JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, Vol.107(4) : 1254-1263, 2019 
Journal Title
 JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS 
ISSN
 1552-4973 
Issue Date
2019
Abstract
Defect-specific bone regeneration using 3-dimensional (3D) printing of block bone has been developed. Polycaprolactone (PCL) is biocompatible polymer that can be used as 3D scaffold. The aim of this study is to assess the biocompatibility and osteogenic efficacy of 3D printed PCL scaffold and to evaluate the effectiveness of β-tricalcium phosphate (β-TCP) addition in PCL scaffold. In this work, four circular defects (diameter: 8 mm) in rabbit calvarium were randomly assigned to (1) negative control (control), (2) PCL block (PCL), (3) PCL mixed with 10 wt% β-TCP (PCL/β-TCP), and (4) PCL/β-TCP plus collagen membrane (PCL/β-TCP + M). Animals were euthanized at 2 (n = 5) and 8 weeks (n = 5). Results indicated that in micro-CT, PCL/β-TCP + M showed the highest total augmented volume and new bone volume at 8 weeks, but there was no significant difference among four groups. Histomorphometrically, PCL, PCL/β-TCP, and PCL/β-TCP + M showed the significantly higher total augmented area compared to the control. PCL/β-TCP + M showed the highest new bone area but not statistically higher than the control. New bone formation deep inside the scaffold was observed only in β-TCP added scaffold. PCL showed high biocompatibility with great volume maintenance. Addition of β-TCP to PCL seemed to increase hydrophilicity and osteoconductivity. Developments in 3D-printed PCL material are expected.
Full Text
https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.b.34218
DOI
10.1002/jbm.b.34218
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Joo Hyun(강주현)
Pae, Hyung-Chul(배형철) ORCID logo https://orcid.org/0000-0002-6365-3557
Paik, Jeong Won(백정원) ORCID logo https://orcid.org/0000-0002-5554-8503
Jung, Ui Won(정의원) ORCID logo https://orcid.org/0000-0001-6371-4172
Cha, Jae Kook(차재국) ORCID logo https://orcid.org/0000-0001-6817-9834
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/164980
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