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부분 뇌하수체기능저하증을 동반한 인슐린자가면역증후군 1예

Other Titles
 A Case of Insulin Autoimmune Syndrome in a Patient with Partial Hypopituitarism 
 권오빈  ;  박은영  ;  윤진영  ;  김광준  ;  이용호  ;  홍재원  ;  이은직  ;  임승길  ;  이현철  ;  차봉수 
 Endocrinology and Metabolism (대한내분비학회지), Vol.24(4) : 281-286, 2009 
Journal Title
Endocrinology and Metabolism(대한내분비학회지)
Issue Date
corticosteroid ; hypopituitarism ; insulin autoimmune syndrome
Insulin autoimmune syndrome is one of the rare causes of hypoglycemia, and characterized by
hyperinsulinemic hypoglycemia associated with high titer of antibodies to endogenous insulin. We report a case
of insulin autoimmune syndrome in a 57-year-old woman, presenting with mental changes due to
hypoglycemia. She had no history of diabetes or insulin administration. The serum C-peptide level was 4.69
ng/mL and the insulin concentration was 229.55 μU/mL, when fasting plasma glucose level was 32 mg/dL.
The insulin-to-glucose ratio was 7.17, while there was no radiologic evidence of insulinoma. The insulin
antibody level was over 100 μU/mL, resulting in the diagnosis of insulin autoimmune syndrome. Hormonal
studies revealed partial hypopituitarism and a lack of glucagon-response to hypoglycemia. Hypoglycemia
disappeared with replacement of prednisolone with levothyroxine therapy. Under secretion of growth hormone
and of adrenocorticotropic hormone due to hypopituitarism were associated with insufficient counterregulation
to hypoglycemia. One should keep in mind that insulin autoimmune syndrome or hypopituitarism is one cause
of hypoglycemia in patients with no history of diabetes, and corticosteroid can be an effective treatment for
both diseases.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kwang Joon(김광준) ORCID logo https://orcid.org/0000-0002-5554-8255
Lee, Yong Ho(이용호) ORCID logo https://orcid.org/0000-0002-6219-4942
Lee, Eun Jig(이은직) ORCID logo https://orcid.org/0000-0002-9876-8370
Lee, Hyun Chul(이현철)
Lim, Sung Kil(임승길)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
Hong, Jae Won(홍재원)
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