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Impaired finger dexterity and nigrostriatal dopamine loss in Parkinson's disease

Authors
 S. H. Lee  ;  M. J. Lee  ;  C. H. Lyoo  ;  H. Cho  ;  M. S. Lee 
Citation
 Journal of Neural Transmission, Vol.125(9) : 1333-1339, 2018 
Journal Title
 Journal of Neural Transmission 
ISSN
 0300-9564 
Issue Date
2018
Keywords
Dopamine transporter ; Finger dexterity ; Parkinson’s disease ; Positron emission tomography
Abstract
Impaired finger dexterity occurs in Parkinson's disease (PD) and has been considered a limb-kinetic apraxia associated with primary sensory cortical dysfunction. To study the role of nigrostriatal dopamine loss and elementary parkinsonian motor deficits in impaired finger dexterity of PD. Thirty-two right-handed untreated PD patients and 30 right-handed healthy controls were included. All patients underwent [18F] FP-CIT positron emission tomography studies. We examined the associations among unilateral coin rotation (CR) score, Unified Parkinson's Disease Rating Scale (UPDRS) subscores for bradykinesia and rigidity of the corresponding arm, and contralateral regional striatal dopamine transporter (DAT) uptake. We also measured the effect of oral levodopa dose on CR scores and UPDRS subscores. PD patients performed worse than controls on the CR task. Unilateral arm UPDRS bradykinesia scores were associated with DAT uptake in the contralateral putamen. The left CR score was associated with left arm bradykinesia and rigidity scores and DAT uptake in the right posterior putamen, whereas no such associations were found for the right CR score. There was a significant effect of handedness on the association of putamen DAT uptake with CR scores, but not with UPDRS subscores. An oral levodopa challenge improved CR scores and UPDRS subscores on both sides. Impaired finger dexterity in PD is related to elementary parkinsonian motor deficits and nigrostriatal dopamine loss. Impaired dominant hand dexterity associated with nigrostriatal dopamine loss seems to be compensated to some extent by the dominant cerebral cortex specialized for controlling precise finger movements
Full Text
https://link.springer.com/article/10.1007%2Fs00702-018-1901-5
DOI
10.1007/s00702-018-1901-5
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실)
Yonsei Authors
류철형(Lyoo, Chul Hyoung)
이명식(Lee, Myung Sik)
이승하(Lee, Seung Ha)
조한나(Cho, Hanna)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/163756
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