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Association between Serum Immnunoglobulin E and Pterygium: A Population-Based Study from South Korea

Authors
 Tae Keun Yoo  ;  Sun Woong Kim  ;  Kyoung Yul Seo 
Citation
 Current Eye Research, Vol.43(9) : 1090-1096, 2018 
Journal Title
 Current Eye Research 
ISSN
 0271-3683 
Issue Date
2018
Keywords
Pterygium ; South Korea ; allergy ; immunoglobulin E ; inflammation
Abstract
PURPOSE: Several studies have shown that pterygium is associated with inflammation, angiogenesis, and fibrosis. However, it should be acknowledged that not enough is known about the association between immunoglobulin E (IgE) and pterygium. The present study was conducted to test the hypothesis that elevated serum IgE is associated with a greater prevalence of pterygium. MATERIAL AND METHODS: A cross-sectional study was performed using data of 1,548 participants aged 30 years or older who were enrolled in the Korea National Health and Nutrition Examination Survey conducted in 2010. Multivariable logistic regression analysis was used to examine the relationship between pterygium and allergic conditions, including total serum IgE and allergen-specific serum IgE levels, after adjusting for potential confounding factors. RESULTS: Participants with pterygium were more likely have increased IgE level (p = 0.009). After adjusting for potential confounders, the odds ratio (OR) for pterygium was greater in participants with higher total serum IgE levels (OR = 1.63; p = 0.047). Multivariable-adjusted ORs of pterygium across the tertile of increasing IgE were 1.00 (reference), 1.18, and 1.45, (P for linear trend = 0.038). Although the ORs for the upper two tertiles of cockroach and dog allergen-specific IgE were higher than those for the lowest tertile, allergen-specific serum IgE showed no clear association with pterygium. CONCLUSIONS: Increased total serum IgE concentration is independently related to pterygium after adjusting for confounding factors. To the best of our knowledge, this study is the first research that reveals an association between serum IgE and pterygium.
Full Text
https://www.tandfonline.com/doi/full/10.1080/02713683.2018.1484145
DOI
10.1080/02713683.2018.1484145
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Seo, Kyuong Yul(서경률) ORCID logo https://orcid.org/0000-0002-9855-1980
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/163753
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