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Olfactory dysfunction in Alzheimer's disease- and Lewy body-related cognitive impairment

Authors
 Han Soo Yoo  ;  Seun Jeon  ;  Seok Jong Chung  ;  Mijin Yun  ;  Phil Hyu Lee  ;  Young Ho Sohn  ;  Alan C. Evans  ;  Byoung Seok Ye 
Citation
 Alzheimer's & Dementia, Vol.14(10) : 1243-1252, 2018 
Journal Title
 Alzheimer's & Dementia 
ISSN
 1552-5260 
Issue Date
2018
Keywords
Alzheimer's disease ; Cognitive impairment ; Cortical atrophy ; Dementia with Lewy bodies ; Olfaction ; Parkinson's disease
Abstract
INTRODUCTION: Olfactory dysfunction is common in Alzheimer's disease- and Lewy body-related disorders, but its neural correlates have not been clearly elucidated. METHODS: We retrospectively recruited 237 patients with Alzheimer's disease-related cognitive impairment (ADCI) and 217 with Lewy body-related cognitive impairment (LBCI). They were identically evaluated using the Cross-Cultural Smell Identification Test, neuropsychological tests, and brain magnetic resonance imaging. RESULTS: LBCI had more severe olfactory dysfunction than ADCI. Patients with more severe cognitive dysfunction had worse olfactory function in both groups. In ADCI, lower Cross-Cultural Smell Identification Test scores correlated with a lower cortical thickness in brain regions typically affected in Alzheimer's disease, most prominently in the right parahippocampal cortex, whereas in LBCI, the scores correlated with white matter abnormalities in regions vulnerable to Lewy body, including subcortical regions of the orbitofrontal and frontoparietal cortices. DISCUSSION: Our results suggest that cortical atrophy in ADCI and white matter abnormalities in LBCI play important roles in olfactory dysfunction.
Full Text
https://www.sciencedirect.com/science/article/pii/S155252601830164X
DOI
10.1016/j.jalz.2018.05.010
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실)
Yonsei Authors
손영호(Sohn, Young Ho) ORCID logo https://orcid.org/0000-0001-6533-2610
예병석(Ye, Byoung Seok) ORCID logo https://orcid.org/0000-0003-0187-8440
유한수(Yoo, Han Soo) ORCID logo https://orcid.org/0000-0001-7846-6271
윤미진(Yun, Mi Jin) ORCID logo https://orcid.org/0000-0002-1712-163X
이필휴(Lee, Phil Hyu)
정석종(Chung, Seok Jong) ORCID logo https://orcid.org/0000-0001-6086-3199
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/163747
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