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Cardiac function associated with home ventilator care in Duchenne muscular dystrophy

Authors
 Sangheun Lee  ;  Heeyoung Lee  ;  Lucy Youngmin Eun  ;  Seung Woong Gang 
Citation
 Korean Journal of Pediatrics, Vol.61(2) : 59-63, 2018 
Journal Title
 Korean Journal of Pediatrics 
ISSN
 1738-1061 
Issue Date
2018
Keywords
Cardiac function test ; Duchenne muscular dystrophy ; Mechanical ventilators
Abstract
Purpose: Cardiomyopathy is becoming the leading cause of death in patients with Duchenne muscular dystrophy because mechanically assisted lung ventilation and assisted coughing have helped resolve respiratory complications. To clarify cardiopulmonary function, we compared cardiac function between the home ventilator-assisted and non-ventilator-assisted groups. Methods: We retrospectively reviewed patients with Duchenne muscular dystrophy from January 2010 to March 2016 at Gangnam Severance Hospital. Demographic characteristics, pulmonary function, and echocardiography data were investigated. Results: Fifty-four patients with Duchenne muscular dystrophy were divided into 2 groups: home ventilator-assisted and non-ventilator-assisted. The patients in the home ventilator group were older (16.25±1.85 years) than those in the nonventilator group (14.73±1.36 years) (P=0.001). Height, weight, and body surface area did not differ significantly between groups. The home ventilator group had a lower seated functional vital capacity (1,038±620.41 mL) than the nonventilator group (1,455±603.12 mL). Mean left ventricular ejection fraction and fractional shortening were greater in the home ventilator group, but the data did not show any statistical difference. The early ventricular filling velocity/late ventricular filling velocity ratio (1.7±0.44) was lower in the home ventilator group than in the nonventilator group (2.02±0.62). The mitral valve annular systolic velocity was higher in the home ventilator group (estimated β, 1.06; standard error, 0.48). Patients with Duchenne muscular dystrophy on a ventilator may have better systolic and diastolic cardiac functions. Conclusion: Noninvasive ventilator assistance can help preserve cardiac function. Therefore, early utilization of noninvasive ventilation or oxygen may positively influence cardiac function in patients with Duchenne muscular dystrophy.
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DOI
10.3345/kjp.2018.61.2.59
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
강성웅(Kang, Seong Woong) ORCID logo https://orcid.org/0000-0002-7279-3893
은영민(Eun, Lucy Youngmin) ORCID logo https://orcid.org/0000-0002-4577-3168
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/163728
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