Accumulating evidence suggests that cancer, cardiovascular disease, atherosclerosis, type 2 diabetes, metabolic syndrome,
sarcopenia, and autonomic dysfunction could be predicted by using leukocyte count and clinical chemistry tests in addition
to the traditional interpretations. This review focused on the integrative interpretations of complete blood count (CBC) and
clinical chemistry from functional medicine perspectives. We conducted a review to assess the epidemiological associations
between CBC and clinical chemistry from the database of PubMed, EMBASE, Cochrane. The CBC tests such as leukocyte
count and platelet count and clinical chemistry tests including serum blood glucose, lipid profiles, liver enzymes, uric acid,
and bilirubin are widely performed in primary care setting. Cancer, cardiovascular disease, and cerebrovascular disease are
the three major causes of death in developed countries, wherein the crucial pathophysiology involves oxidative stress and
chronic low-grade inflammation. Low-grade inflammation accumulates due to the combination of innate constitution, detoxification,
intestinal health, resilience to cope with stress, lifestyle behaviors including smoking, drinking and sleep, which in turn leads
to higher inflammatory markers in blood. On the other hand, individuals with weakness also express various symptoms. Frailty
is a common complication in patients with multiple discomforts such as sarcopenia, chronic fatigue, headache, dizziness, poor
circulation, and multiple pain. Thus, it is important to understand who is in inflammation or in a weak state from a functional
medicine perspective. CBC or clinical chemistry may help to identify individuals who are not functionally optimally are often
in chronic inflammation or frailty state.