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Clinical outcomes of radiotherapy for spinal cord ependymoma with adverse prognostic features: a single-center study.

Authors
 Hwa Kyung Byun  ;  Seong Yi  ;  Hong In Yoon  ;  Se Hoon Kim  ;  Jaeho Cho  ;  Chang-Ok Suh 
Citation
 Journal of Neuro-Oncology, : ePub,, 2018 
Journal Title
 Journal of Neuro-Oncology 
ISSN
 0167-594X 
Issue Date
2018
Keywords
Adverse prognostic features ; Incomplete resection ; Radiotherapy ; Spinal cord ; Spinal ependymoma
Abstract
PURPOSE: This study evaluated the outcomes of radiotherapy (RT) for spinal ependymoma with adverse features, such as incomplete resection or disseminated disease. METHODS: Twenty-five patients underwent RT for spinal cord ependymoma during 1991-2016. Twenty-four patients had gross disease on the pre-RT spinal magnetic resonance images. Six patients (24%) had disseminated disease. The World Health Organization grades were I (12 patients), II (12 patients), and III (1 patient). The RT fields were the tumor bed plus margin in 19 patients (76%), the entire craniospinal axis in 5 patients (20%), and the entire spinal canal with posterior cranial fossa in 1 patient (4%). The median RT dose was 50.4 Gy (range 44.0-59.4 Gy). RESULTS: The median follow-up was 49 months (range 9-321 months), with 5-year overall and progression-free survival rates of 83.7% and 70.8%, respectively. Relative to patients with grade II/III ependymoma, patients with grade I ependymoma had higher 5-year rates of overall survival (100% vs. 69.4%, P = .088) and progression-free survival (100% vs. 42.3%, P = .02). Disease progression was observed in 4 patients who had grade II ependymoma, including 2 of 6 patients with disseminated disease and 2 of 19 patients with localized disease. Twelve patients (48%) exhibited improved neurological function. One patient who underwent craniospinal irradiation developed late hypopituitarism. No other RT-related late toxicities were observed. CONCLUSIONS: Favorable survival outcomes were achieved using RT for spinal ependymoma with adverse prognostic features. Thus, RT may be an effective treatment option when complete tumor removal cannot be achieved.
DOI
10.1007/s11060-018-2995-1
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실)
Yonsei Authors
김세훈(Kim, Se Hoon) ORCID logo https://orcid.org/0000-0001-7516-7372
변화경(Byun, Hwa Kyung) ORCID logo https://orcid.org/0000-0002-8964-6275
서창옥(Suh, Chang Ok)
윤홍인(Yoon, Hong In) ORCID logo https://orcid.org/0000-0002-2106-6856
이성(Yi, Seong)
조재호(Cho, Jae Ho) ORCID logo https://orcid.org/0000-0001-9966-5157
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/163478
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