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Protective effect of Korean red ginseng on oxaliplatin-mediated splenomegaly in colon cancer

 Jeonghyun Kang  ;  Joon Seong Park  ;  Sung Gwe Ahn  ;  Jin Hong Lim  ;  Seung Hyuk Baik  ;  Dong Sup Yoon  ;  Kang Young Lee  ;  Joon Jeong 
 Annals of Surgical Treatment and Research, Vol.95(3) : 161-167, 2018 
Journal Title
 Annals of Surgical Treatment and Research 
Issue Date
Colonic neoplasms ; Folfox protocol ; Oxaliplatin ; Splenomegaly
Purpose: This study investigated how adding Korean red ginseng extract (KRG) to folinic acid, fluorouracil and oxaliplatin (FOLFOX) chemotherapy affected the rate of splenomegaly in colon cancer. Methods: This retrospective study analyzed 42 patients who were randomly assigned to receive a FOLFOX regimen with or without KRG. Spleen volume change was assessed by computed tomography scans measured before surgery (presurgery volume) and 3 weeks after cessation of the 12th cycle of FOLFOX (postchemotherapy volume). Results: All patients showed increased spleen volume. No difference was observed in median presurgery and postchemotherapy volume between the KRG and control groups. However, a ratio defined as postchemotherapy volume divided by presurgery volume was significantly lower in the KRG group than the control group (median, 1.38 [range, 1.0-2.8] in KRG group vs. median, 1.89 [range, 1.1-3.0] in control group, P = 0.028). When splenomegaly was defined as a >61% increase in spleen volume, the rate of splenomegaly was significantly lower in the KRG group than the control group (28.6% vs. 61.9%, P = 0.03). KRG consumption was inversely associated with developing splenomegaly in multivariate analysis. Conclusion: Adding KRG during FOLFOX chemotherapy for colon cancer might protect against oxaliplatin-induced splenomegaly. The protective effect of Korean red ginseng should be investigated with further research.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
Yonsei Authors
강정현(Kang, Jeonghyun) ORCID logo https://orcid.org/0000-0001-7311-6053
박준성(Park, Joon Seong) ORCID logo https://orcid.org/0000-0001-8048-9990
백승혁(Baik, Seung Hyuk)
안성귀(Ahn, Sung Gwe) ORCID logo https://orcid.org/0000-0002-8778-9686
윤동섭(Yoon, Dong Sup)
이강영(Lee, Kang Young)
임진홍(Lim, Jin Hong)
정준(Jeong, Joon) ORCID logo https://orcid.org/0000-0003-0397-0005
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